Understanding the development and dysfunction of the human brain is a major goal of
neurobiology. Much of our current understanding of human brain development has been …

Brain organoids have rapidly become established as promising tools for studying both the
normal embryonic development of the brain and the mechanistic roots of …

The ability to reproduce early stages of human neurodevelopment in the laboratory is one of
the most exciting fields in modern neuroscience. The inaccessibility of the healthy human …

The current understanding of neurological diseases is derived mostly from direct analysis of
patients and from animal models of disease. However, most patient studies do not capture …

The human brain is often described as the most complex organ in our body. Because of the
limited accessibility of living brain tissue, human-specific features of neurodevelopment and …

Human brain development exhibits several unique aspects, such as increased complexity
and expansion of neuronal output, that have proven difficult to study in model organisms. As …

Abstract Three-dimensional (3D) brain organoids derived from human pluripotent stem cells
(hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) …

Studying the etiology of human neurodevelopmental diseases has long been a challenging
task due to the brain's complexity and its limited accessibility. Human pluripotent stem cells …

Understanding etiology of human neurological and psychiatric diseases is challenging.
Genomic changes, protracted development, and histological features unique to human brain …

Brain organoids are three-dimensional (3D) structures derived from human pluripotent stem
cells (hPSCs) that reflect early brain organization. These organoids contain different cell …