There are three major subfamilies of mitogen-activated protein kinases (MAPK): the
extracellular-signal-regulated kinases (ERK MAPK); the c-jun N-terminal kinase or stress …

The mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathway
is activated by upstream genomic events and/or activation of multiple signaling events in …

About 40% of colorectal cancers have mutations in KRAS accompanied by downstream
activation of MAPK signaling, which promotes tumor invasion and progression. Here, we …

Background: Combined targeting of MAPK and PI3K signalling pathways may be necessary
for optimal therapeutic activity in cancer. This study evaluated the MEK inhibitors AZD6244 …

Colorectal cancer is the third most common malignancy in men and the second most
common cancer in women. Despite the success of screening programs and the …

The identification of intracellular signaling cascades important for the growth and survival of
cancer cells has led to the development of targeted cancer therapeutics aimed at blocking …

Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …

The mitogen-activated protein kinase pathway is thought to be essential in cellular growth
and differentiation. Here we report the discovery of a highly potent and selective inhibitor of …

Pharmacological treatment of colorectal carcinoma currently proceeds through the
administration of a combination of different chemotherapeutic agents. In the case of rectal …

The mitogen-activated extracellular signal-regulated kinase (MEK) pathway is one of the
best-characterized kinase cascades in cancer cell biology. It is triggered by either growth …