The role of calcium in capsaicin-induced desensitization in rat cultured dorsal root ganglion neurons

A Cholewinski, GM Burgess, S Bevan - Neuroscience, 1993 - Elsevier
The effects of capsaicin cytosolic Ca 2+ concentration ([Ca 2+] i) were measured in
individual dorsal root ganglion neurons of the rat in culture. Capsaicin produced a rapid …

Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats

RJ Docherty, JC Yeats, S Bevan, H Boddeke - Pflügers Archiv, 1996 - Springer
Capsaicin activates a non-specific cation conductance in mammalian sensory neurones. If
capsaicin is applied continuously or repeatedly then there is a progressive decline in …

The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons

PA Koplas, RL Rosenberg, GS Oxford - Journal of Neuroscience, 1997 - Soc Neuroscience
Capsaicin (Cap) is a pungent extract of the Capsicum pepper family, which activates
nociceptive primary sensory neurons. Inward current and membrane potential responses of …

Effects of capsaicin on Ca2+ release from the intracellular Ca2+ stores in the dorsal root ganglion cells of adult rats

SY Eun, SJ Jung, YK Park, J Kwak, SJ Kim… - … and Biophysical Research …, 2001 - Elsevier
We have investigated the effect of capsaicin on Ca2+ release from the intracellular calcium
stores. Intracellular calcium concentration ([Ca2+] i) was measured in rat dorsal root …

Capsaicin causes prolonged inhibition of voltage-activated calcium currents in adult rat dorsal root ganglion neurons in culture

RJ Docherty, B Robertson, S Bevan - Neuroscience, 1991 - Elsevier
The effect of capsaicin on voltage-activated calcium currents was investigated in
voltageclamped somata of cultured adult rat dorsal root ganglion neurons. About half the …

The effect of capsaicin on voltage‐gated calcium currents and calcium signals in cultured dorsal root ganglion cells

D Bleakman, JR Brorson… - British journal of …, 1990 - Wiley Online Library
1 The effects of capsaicin on voltage‐gated Ca2+ currents (ICa), and intracellular Ca2+
concentrations ([Ca2+] i) in cultured dorsal root ganglion (DRG) neurones of the rat were …

[HTML][HTML] Multiple capsaicin-induced currents in isolated rat sensory neurons

M Petersen, RH Lamotte, A Klusch, KD Kniffki - Neuroscience, 1996 - Elsevier
The response to capsaicin in functional assays suggests multiple sites of capsaicin action.
This hypothesis is supported by the results of the present patch-clamp study of isolated …

The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro

SJ Marsh, CE Stansfeld, DA Brown, R Davey… - Neuroscience, 1987 - Elsevier
The selective excitant and neurotoxic action of capsaicin on vagal sensory neurons in the rat
has been investigated in vitro using three techniques: extracellular recording of compound …

Low pH facilitates capsaicin responses in isolated sensory neurons of the rat

M Kress, S Fetzer, PW Reeh, L Vyklicky - Neuroscience letters, 1996 - Elsevier
The effects of capsaicin (CAPS; 30 nM, 300 nM, 3 μM) and acidic solutions (pH 6.6, 6.1, 5.6,
5.1) were studied in dorsal root ganglion (DRG) neurons from adult rats in short term culture …

Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture

JN Wood, J Winter, IF James, HP Rang… - Journal of …, 1988 - Soc Neuroscience
Capsaicin is a pungent pain-producing compound found in plants of the capsicum family; it
exerts excitatory, desensitizing, and toxic effects on a subset of sensory neurons, including …