Despite the high incidence of acute metabolic acidosis, there are no reliable human data to
enable physicians to accurately diagnose this disorder. In addition, there is uncertainty …

We screened the laboratory data of 50 chronic hemodialysis patients selected randomly
over a 21-month period to generate 158 data points which identified two groups:(1) those …

Studies by Schwartz and colleagues at Tufts University School of Medicine in the 1960s
described the “whole-body” acid-base response (ie, secondary changes in plasma [HCO 3−] …

The application of modern quantitative physical chemical techniques to clinical acid-base
has yielded important new information about the nature and clinical significance of …

Acid-base homeostasis and pH regulation are critical for both normal physiology and cell
metabolism and function. The importance of this regulation is evidenced by a variety of …

Data from 41 ambulatory patients with graded degrees of uncomplicated, chronic renal
failure were used to define the quantitative relationship between serum acid-base and …

In complex clinical problems, blood gas analysis is seldom sufficient to determine the
etiology of abnormality. It can and should provide a predse measure of the two components …

Metabolic acidosis is a condition that is commonly encountered in both chronic renal failure
and in end-stage renal disease. Metabolic acidosis is associated with many adverse effects …

The physiologic approach has long been used in assessing acid-base status. This approach
considers acids as hydrogen ion donors and bases as hydrogen ion acceptors and the acid …

The term renal tubular acidosis (RTA) is applied to a group of transport defects in the
reabsorption of bicarbonate (HCO3 J), the excretion of hydrogen ion (H+), or both. This …