Lamins are the key components of the nuclear lamina and by virtue of their interactions with
chromatin and binding partners act as regulators of cell proliferation and differentiation. Of …

Lamins are multifunctional proteins that are often aberrantly expressed or localized in
tumours. Here, we endeavour to assess their uses as cancer biomarkers: to diagnose …

For nearly 60 years, diagnosis of cancer has been based on pathological tests that look for
enlargement and distortion of nuclear shape. Because of their involvement in supporting …

Lung cancer represents the primary cause of cancer death in the world. Malignant cells
identification and characterization are crucial for the diagnosis and management of patients …

Not long after the discovery of lamin proteins, it became clear that not all lamin subtypes are
ubiquitously expressed in cells and tissues. Especially, A-type lamins showed an inverse …

Glioma is the most common type of tumor in the central nervous system, accounting for
around 80% of all malignant brain tumors. Previous studies showed a significant association …

The nuclear lamina, a network of lamin filaments and lamin-associated proteins, is located
between the inner nuclear membrane and the peripheral chromatin. The nuclear lamina is …

Lamins are the major architectural proteins of the nucleus and are essential for nuclear
integrity and assembly. Lamins are also involved in the organization of nuclear functions …

The nuclear lamina is essential for the maintenance of nuclear shape and mechanics.
Mutations in lamin genes have been identified in a heterogeneous spectrum of human …

• The lamin molecule‐Domain organization of lamins‐Lamins are divided to type A and type
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …