[HTML][HTML] Clinical insights into novel immune checkpoint inhibitors
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte
associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1) …
associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1) …
Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment
Significant technological advances in radiotherapy have been made in the past few
decades. High-precision radiotherapy has recently become popular and is contributing to …
decades. High-precision radiotherapy has recently become popular and is contributing to …
[HTML][HTML] Resistance to checkpoint inhibition in cancer immunotherapy
L Barrueto, F Caminero, L Cash, C Makris… - Translational …, 2020 - Elsevier
The interaction of the host immune system with tumor cells in the tissue microenvironment is
essential in understanding tumor immunity and development of successful cancer …
essential in understanding tumor immunity and development of successful cancer …
[HTML][HTML] A snapshot of the PD-1/PD-L1 pathway
Cancer cells can evade the attack from host immune systems via hijacking the regulatory
circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by …
circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by …
Effect of radiotherapy on T cell and PD-1/PD-L1 blocking therapy in tumor microenvironment
C Chen, Y Liu, B Cui - Human Vaccines & Immunotherapeutics, 2021 - Taylor & Francis
Cancer is a worldwide problem that threatens human health. Radiotherapy plays an
important role in a variety of cancer treatment methods. The administration of radiotherapy …
important role in a variety of cancer treatment methods. The administration of radiotherapy …
Influenza vaccination in cancer patients receiving immune checkpoint inhibitors: A systematic review
F Spagnolo, A Boutros, E Croce… - European Journal of …, 2021 - Wiley Online Library
Background There is a concern that influenza vaccination may increase the incidence of
immune‐related adverse events in patients receiving immune checkpoint inhibitors (ICIs) …
immune‐related adverse events in patients receiving immune checkpoint inhibitors (ICIs) …
Anti‐tumour potential of PD‐L1/PD‐1 post‐translational modifications
S Zhou, J Zhu, J Xu, B Gu, Q Zhao, C Luo, Z Gao… - …, 2022 - Wiley Online Library
The immune checkpoint programmed death receptor 1 (PD‐1) and programmed death
ligand 1 (PD‐L1) are biologically important immunosuppressive molecules, and the PD …
ligand 1 (PD‐L1) are biologically important immunosuppressive molecules, and the PD …
Study and analysis of antitumor resistance mechanism of PD1/PD‐L1 immune checkpoint blocker
Z Wang, X Wu - Cancer medicine, 2020 - Wiley Online Library
Immunocheckpoint proteins of tumor infiltrating lymphocytes play an important role in tumor
prognosis in the course of tumor clinicopathology. PD‐1 (Programmed cell death protein 1) …
prognosis in the course of tumor clinicopathology. PD‐1 (Programmed cell death protein 1) …
Targeting TIGIT for immunotherapy of cancer: update on clinical development
A Rotte, S Sahasranaman, N Budha - Biomedicines, 2021 - mdpi.com
Immune checkpoint blockers have dramatically improved the chances of survival in patients
with metastatic cancer, but only a subset of the patients respond to treatment. Search for …
with metastatic cancer, but only a subset of the patients respond to treatment. Search for …
High-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells
Immune checkpoint molecules are important in differentiating between “friend and foe” in the
human immune response and are particularly well known for their impact on anti-cancer …
human immune response and are particularly well known for their impact on anti-cancer …