[HTML][HTML] Clinical insights into novel immune checkpoint inhibitors

JB Lee, SJ Ha, HR Kim - Frontiers in Pharmacology, 2021 - frontiersin.org
The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte
associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1) …

Rationale of combination of anti-PD-1/PD-L1 antibody therapy and radiotherapy for cancer treatment

H Sato, N Okonogi, T Nakano - International Journal of clinical oncology, 2020 - Springer
Significant technological advances in radiotherapy have been made in the past few
decades. High-precision radiotherapy has recently become popular and is contributing to …

[HTML][HTML] Resistance to checkpoint inhibition in cancer immunotherapy

L Barrueto, F Caminero, L Cash, C Makris… - Translational …, 2020 - Elsevier
The interaction of the host immune system with tumor cells in the tissue microenvironment is
essential in understanding tumor immunity and development of successful cancer …

[HTML][HTML] A snapshot of the PD-1/PD-L1 pathway

C Ghosh, G Luong, Y Sun - Journal of Cancer, 2021 - ncbi.nlm.nih.gov
Cancer cells can evade the attack from host immune systems via hijacking the regulatory
circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by …

Effect of radiotherapy on T cell and PD-1/PD-L1 blocking therapy in tumor microenvironment

C Chen, Y Liu, B Cui - Human Vaccines & Immunotherapeutics, 2021 - Taylor & Francis
Cancer is a worldwide problem that threatens human health. Radiotherapy plays an
important role in a variety of cancer treatment methods. The administration of radiotherapy …

Influenza vaccination in cancer patients receiving immune checkpoint inhibitors: A systematic review

F Spagnolo, A Boutros, E Croce… - European Journal of …, 2021 - Wiley Online Library
Background There is a concern that influenza vaccination may increase the incidence of
immune‐related adverse events in patients receiving immune checkpoint inhibitors (ICIs) …

Anti‐tumour potential of PD‐L1/PD‐1 post‐translational modifications

S Zhou, J Zhu, J Xu, B Gu, Q Zhao, C Luo, Z Gao… - …, 2022 - Wiley Online Library
The immune checkpoint programmed death receptor 1 (PD‐1) and programmed death
ligand 1 (PD‐L1) are biologically important immunosuppressive molecules, and the PD …

Study and analysis of antitumor resistance mechanism of PD1/PD‐L1 immune checkpoint blocker

Z Wang, X Wu - Cancer medicine, 2020 - Wiley Online Library
Immunocheckpoint proteins of tumor infiltrating lymphocytes play an important role in tumor
prognosis in the course of tumor clinicopathology. PD‐1 (Programmed cell death protein 1) …

Targeting TIGIT for immunotherapy of cancer: update on clinical development

A Rotte, S Sahasranaman, N Budha - Biomedicines, 2021 - mdpi.com
Immune checkpoint blockers have dramatically improved the chances of survival in patients
with metastatic cancer, but only a subset of the patients respond to treatment. Search for …

High-potency PD-1/PD-L1 degradation induced by Peptide-PROTAC in human cancer cells

MY Dai, YY Shi, AJ Wang, XL Liu, M Liu, HB Cai - Cell Death & Disease, 2022 - nature.com
Immune checkpoint molecules are important in differentiating between “friend and foe” in the
human immune response and are particularly well known for their impact on anti-cancer …