Targeting macrophage immunometabolism: Dawn in the darkness of sepsis

V Kumar - International Immunopharmacology, 2018 - Elsevier
Sepsis is known since the time (470 BC) of great Greek physician, Hippocrates.
Advancement in modern medicine and establishment of separate branches of medical …

Immunometabolism: another road to sepsis and its therapeutic targeting

V Kumar - Inflammation, 2019 - Springer
Sepsis is a major health problem all over the world. Despite its existence since the time of
Hippocrates (470 BC), sepsis is still a serious medical problem for physicians working in …

Treatment advances in sepsis and septic shock: modulating pro-and anti-inflammatory mechanisms

A Marques, C Torre, R Pinto, B Sepodes… - Journal of Clinical …, 2023 - mdpi.com
Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated
host response to infection, and it affects over 25 million people every year. Even more …

Current trends in inflammatory and immunomodulatory mediators in sepsis

M Aziz, A Jacob, WL Yang, A Matsuda… - Journal of leukocyte …, 2013 - academic.oup.com
Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

RS Hotchkiss, G Monneret, D Payen - Nature Reviews Immunology, 2013 - nature.com
Sepsis—which is a severe life-threatening infection with organ dysfunction—initiates a
complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be …

Therapeutic approaches to innate immunity: severe sepsis and septic shock

E Lolis, R Bucala - Nature reviews Drug discovery, 2003 - nature.com
Severe sepsis leading to shock is the principal cause of death in non-cardiac intensive care
units. This condition develops because of a dysregulation in host responses, such that the …

[HTML][HTML] Sepsis: from bench to bedside

E Silva, RDH Passos, MB Ferri, LFP de Figueiredo - Clinics, 2008 - Elsevier
Sepsis is a syndrome related to severe infections. It is defined as the systemic host response
to microorganisms in previously sterile tissues and is characterized by end-organ …

Immunosuppression in sepsis

K Lyn-Kew, TJ Standiford - Current pharmaceutical design, 2008 - ingentaconnect.com
The often fatal sepsis syndrome is characterized by the systemic release of inflammatory
mediators, which is regulated and counterbalanced by the coordinated expression of anti …

[HTML][HTML] Sepsis—pathophysiology and therapeutic concepts

D Jarczak, S Kluge, A Nierhaus - Frontiers in medicine, 2021 - frontiersin.org
Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

[HTML][HTML] Precision immunotherapy for sepsis

AM Peters van Ton, M Kox, WF Abdo… - Frontiers in …, 2018 - frontiersin.org
Decades of sepsis research into a specific immune system-targeting adjunctive therapy
have not resulted in the discovery of an effective compound. Apart from antibiotics, source …