SUPERANTIGENS (SAgs) are viral or bacterial proteins that act as potent T-cell stimulants
and have been implicated in a number of human diseases, including toxic shock …

SUPERANTIGENS stimulate T cells bearing particular T-cell receptor Vβ sequences1, 2, so
they are extremely potent polyclonal T-cell mitogens. T-cell activation is preceded by binding …

SUPERANTIGENS are proteins that in association with class II major histocompatibility
complex (MHC)-bearing cells can stimulate vir-tually all T cells that express particular …

Superantigens (SAGs) are a class of immunostimulatory proteins of bacterial or viral origin
that activate T cells by binding to the Vβ domain of the T cell antigen receptor (TCR). The …

The structure of a bacterial superantigen, Staphylococcus aureus enterotoxin B, bound to a
human class II histocompatibility complex molecule (HLA-DR1) has been determined by X …

Superantigens (SAGs) bind simultaneously to major histocompatibility complex (MHC) and T‐
cell receptor (TCR) molecules, resulting in the massive release of inflammatory cytokines …

The three-dimensional structure of an unglycosylated T cell antigen receptor (TCR) beta
chain has recently been determined to 1.7 A resolution. To investigate whether this soluble …

Bacterial superantigens are small proteins that have a very potent stimulatory effect on T
lymphocytes through their ability to bind to both MHC class II molecules and T-cell receptors …

Superantigens (SAgs) are bacterial toxins that interact with immunoreceptors, T cell receptor
(TCR) and major histocompatibility complex (MHC) class II, conventionally through the …

THE αβ T-cell antigen receptor (TCR) recognizes antigenic peptides in the context of self
major histocompatibility complex (MHC) molecules1–4. The specificity of recognition of MHC …