The efficacy of antidepressant treatment for depression is controversial due to the only
modest superiority demonstrated over placebo. However, neurobiological heterogeneity …

The ability to match individual patients to tailored treatments has the potential to greatly
improve outcomes for individuals suffering from major depression. In particular, while the …

The tail-suspension test (TST) is a widely used assay for screening potential antidepressant
drugs. Its advantages include being a rapid, inexpensive, highly predictive and high …

The mechanisms underlying the initiation/onset of, and the recovery from, depression are
still largely unknown; views that neurogenesis in the hippocampus may be important for the …

Depression is one of the leading causes of disability and a significant health-concern
worldwide. Much of our current understanding on the pathogenesis of depression and the …

Early life adversity (ELA) is a risk factor for major depressive disorder (MDD), however the
underlying mechanisms are not well understood. Clinical studies suggest that negative …

BACKGROUND: Anxiety vulnerability is associated with biases in attention: a tendency to
selectively process negative relative to neutral or positive information. It is not clear whether …

Reduction of the monoamine serotonin (5-HT) via the dietary manipulation of tryptophan
(acute tryptophan depletion; ATD) has been shown to induce negative cognitive biases …

Background: Major depressive disorder (MDD) is a prevalent neuropsychiatric illness for
which it is important to resolve underlying brain mechanisms. Current treatments are often …

BACKGROUND: Negative attentional biases are thought to increase the risk of recurrence in
depression, suggesting that reduction of such biases may be a plausible strategy in the …