Glial cell line‐derived neurotrophic factor prevents death, but not reductions in tyrosine hydroxylase, of injured nigrostriatal neurons in adult rats
X Lu, T Hagg - Journal of Comparative Neurology, 1997 - Wiley Online Library
Glial cell line‐derived neurotrophic factor (GDNF) promotes survival of mesencephalic
dopaminergic neurons in vitro and when injected locally into the brains of lesioned adult …
dopaminergic neurons in vitro and when injected locally into the brains of lesioned adult …
Glial cell line‐derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons
KE Bowenkamp, AF Hoffman… - Journal of …, 1995 - Wiley Online Library
Glial cell‐lined derived neurotrophic factor (GDNF) has been shown to promote survival of
developing mesencephalic dopaminergic neurons in vitro. In order to determine if there is a …
developing mesencephalic dopaminergic neurons in vitro. In order to determine if there is a …
Long‐term protection of the rat nigrostriatal dopaminergic system by glial cell line‐derived neurotrophic factor against 6‐hydroxydopamine in vivo
Blunt - European Journal of Neuroscience, 1998 - Wiley Online Library
Glial cell‐line‐derived neurotrophic factor (GDNF) has been shown to enhance the survival
of dopaminergic neurones both in vitro and in vivo, and to protect the rodent dopaminergic …
of dopaminergic neurones both in vitro and in vivo, and to protect the rodent dopaminergic …
Regulation of natural cell death in dopaminergic neurons of the substantia nigra by striatal glial cell line-derived neurotrophic factor in vivo
TF Oo, N Kholodilov, RE Burke - Journal of Neuroscience, 2003 - Soc Neuroscience
Dopamine (DA) neurons of the substantia nigra undergo a developmental cell death event
that is biphasic, with peaks just after birth and at postnatal day 14. As envisioned by …
that is biphasic, with peaks just after birth and at postnatal day 14. As envisioned by …
Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates
DM Gash, GA Gerhardt, BJ Hoffer - Advances in pharmacology, 1997 - Elsevier
Publisher Summary Glial cell line-derived neurotrophic factor (GDNF) has been found to
play an important role in the survival and development of a variety of cell types throughout …
play an important role in the survival and development of a variety of cell types throughout …
Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo
J Hudson, AC Granholm, GA Gerhardt, MA Henry… - Brain research …, 1995 - Elsevier
Recently, a novel glial cell line-derived neurotrophic factor (GDNF) has been identified,
cloned, and shown to have potent survival-and growth-promoting activity on fetal rat …
cloned, and shown to have potent survival-and growth-promoting activity on fetal rat …
Effects of glial cell line-derived neurotrophic factor (GDNF) on dopaminergic neurons require concurrent activation of cAMP-dependent signaling pathways
J Engele, B Franke - Cell and tissue research, 1996 - Springer
Glial cell line-derived neurotrophic factor (GDNF) is a highly selective neurotrophic factor for
midbrain dopaminergic neurons and might thus be of potential use in the therapy of …
midbrain dopaminergic neurons and might thus be of potential use in the therapy of …
Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo
BJ Hoffer, A Hoffman, K Bowenkamp, P Huettl… - Neuroscience …, 1994 - Elsevier
Fischer 344 rats were unilaterally injected into the medial forebrain bundle with 6-
hydroxydopamine (6-OHDA). Apomorphine-induced rotational behavior was used to select …
hydroxydopamine (6-OHDA). Apomorphine-induced rotational behavior was used to select …
Glial cell line-derived neurotrophic factor protects dopaminergic neurons from 6-hydroxydopamine toxicity in vitro
K Eggert, J Schlegel, W Oertel, C Würz, JC Krieg… - Neuroscience …, 1999 - Elsevier
Glial cell line-derived neurotrophic factor (GDNF) is a potent and specific neurotrophic factor
for dopaminergic neurons. GDNF has been previously shown to protect dopaminergic …
for dopaminergic neurons. GDNF has been previously shown to protect dopaminergic …
Neuroprotective mechanism of glial cell line‐derived neurotrophic factor in mesencephalic neurons
H Sawada, M Ibi, T Kihara, M Urushitani… - Journal of …, 2000 - Wiley Online Library
Glial cell line‐derived neurotrophic factor (GDNF) provides neuroprotection, but its
neuroprotective mechanism has not been resolved. We investigated the neuroprotective …
neuroprotective mechanism has not been resolved. We investigated the neuroprotective …