Background: Prostate cancer (PC) is an ideal target for chemoprevention, with high-grade
prostatic intraepithelial neoplasia (HGPIN) as its most likely precursor finasteride, a 5α …

A68: Randomized presurgical trial of finasteride vs. flutamide vs. placebo in prostate cancer
| Cancer Prevention Research | American Association for Cancer Research Skip to Main …

Purpose: Prostate cancer is the most common male cancer, affecting one man in six.
Prevention of this disease, even in a subset of patients would have a significant impact on …

OBJECTIVE: Presurgical, window of opportunity trials have been proposed as a model to
assess the activity of preventive and therapeutic interventions in a cost-effective manner in …

Abstract Background The Prostate Cancer Prevention Trial (PCPT) reported a decreased
incidence of prostate cancer overall but an increase in the incidence of high-grade prostate …

(1) Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, et al. The
influence of finasteride on the development of prostate cancer. N Engl J Med 2003; 349: 215 …

Abstract Background: The Prostate Cancer Prevention Trial (PCPT) showed a relative
reduction of 24.8% in cumulative incidence of prostate cancer (PC) in finasteride-treated …

Editorial Comment: The Prostate Cancer Prevention Trial (PCPT) identified a 25% decrease
in the risk of prostate cancer following 7 years of finasteride treatment. Since the study was …

Background: Finasteride has been found to reduce the risk of low-grade prostate cancer but
to have no impact on overall survival. The long-term adverse and beneficial consequences …

Despite reports, Finasteride is not yet recommended for routine prevention of prostate
cancer. A recent study has raised new questions that are still being answered. In the mean …