Abstract Prostatic Neoplasms-pathology Prostatic Intraepithelial Neoplasia-pathology
Humans Testosterone-physiology 5-alpha Reductase Inhibitors Male Risk Enzyme Inhibitors …

The Prostate Cancer Prevention Trial, a randomized placebo-controlled study involving
nearly 19,000 men at 221 sites over 10 years, has shown that men who took the drug …

Editorial Comments: The original report from the PCPT (Prostate Cancer Prevention Trial)
demonstrated a 24% relative reduction in the diagnosis of prostate cancer among men with …

OBJECTIVES: To determine the effect of finasteride relative to placebo on prostate cancer
(PCa) risk at each individual Gleason score in the Prostate Cancer Prevention Trial using a …

In this paper, we report ongoing investigations concerning the increased number of high-
grade (Gleason grade> or= 7) prostate cancer, despite a reduction in all prostate cancer …

Although testosterone is the major circulating andro-gen in men, dihydrotestosterone (DHT)
is more potent and is the major form of androgen found within the prostate gland. 1 DHT …

Background In the Prostate Cancer Prevention Trial (PCPT), finasteride significantly reduced
the risk of prostate cancer but was associated with an increased risk of high-grade disease …

CONTEXT: It is now possible to reduce a man's risk of developing biopsy-detectable
prostate cancer. This review addresses the evidence and issues surrounding prostate …

There is little evidence to support the use of finasteride for the prevention of prostate cancer
in men who are at high risk of the disease as indicated by elevated prostate specific antigen …

The findings from the Prostate Cancer Prevention Trial (PCPT) and how they relate to the
management of prostate disease were reviewed by leading European urologists during a …