Osteopontin (OPN) is a phosphorylated glycoprotein possessing an arginine-glycine-
aspartate (RGD)-motif, which binds to several cell surface integrins and mediates a wide …

Osteopontin (OPN) is widely overexpressed in various cancers, including gliomas, and plays
an important role in tumorigenesis. However, the expression pattern and functions of OPN …

Traumatic brain injury (TBI) is the leading cause of death in children and adolescents in
developed countries, but there are no blood-based biomarkers to support the diagnosis or …

Background Osteopontin (OPN) is a highly phosphorylated sialoprotein and a soluble
cytokine that is widely expressed in a variety of tissues, including the brain. OPN and OPN …

Background and Purpose—Recombinant osteopontin (rOPN) has been reported to be
neuroprotective in stroke animal models. The purpose of this study is to investigate a …

Background: Osteopontin, an extracellular matrix protein involved in bone remodeling,
tissue repair and inflammation, has previously been associated with increased inflammation …

Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding
ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many …

Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1
(SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that …

Osteopontin (OPN), a phosphorylated glycoprotein, is induced in response to tissue damage
and inflammation in various organs, including the brain. In our previous studies, we reported …

Recent research has led to a better but as yet incomplete understanding of the complex
roles osteopontin plays in mammalian physiology. A soluble protein found in all body fluids …