Preventive effects of FK506 on autoimmune myocarditis have been demonstrated, but the
therapeutic efficacy of the agent in established myocarditis yet remains to be assessed. In …

A new immunosuppressive compound, FK-506, is a macrolide produced by Streptomyces
tsukubaensis. It is reported that FK-506 prolongs the viability of allogenic grafts of the heart …

To test the therapeutic efficacy of immunosuppression with FK-506 upon coxsackievirus B3
myocarditis, C3H/He mice were inoculated with coxsackievirus B3, and the effects of FK-506 …

The effects of interferon-a A/D (IFN) therapy in combination with various
immunosuppressants were investigated in a murine model of viral myocarditis. Viral …

Objectives. Preventive effects of cyclosporine, prednisolone and aspirin on autoimmune
giant cell myocarditis in rats were investigated. Background. The therapeutic efficacy of …

The effect of immunostimulant therapy on acute viral myocarditis, which was induced with
encephalomyocarditis virus, was investigated in 4-week-old male BALB c mice. In vitro …

Background The benefits of immunosuppressive therapy for human myocarditis are
controversial. The effects of a new immunosuppressant agent, 15-deoxyspergualin (DSG) …

Immunomodulatory Effect of Pentoxifylline in Suppressing Experimental Autoimmune
Myocarditis Page 1 iologically active molecules are important in the pathogenesis of heart …

We investigated the cardioprotective effect of FK506, a newly developed
immunosuppressive agent, on ischemia-reperfusion-induced myocardial damage and the …

Animals and methods. Twenty four, six week-old male Wistar rats were randomly allocated
into 4 groups of 6 rats each. Group I received no treatment. Group II received lisinopril at a …