Ovarian aging is associated with gradual follicular loss by atresia/apoptosis. Increased
production of toxic metabolites such as reactive oxygen species (ROS) and reactive nitrogen …

Granulosa cells are essential for follicle initiation and development, and their abnormal
function or apoptosis is a crucial factor leading to follicular atresia. A state of oxidative stress …

Studies on elevated reactive oxygen species (ROS) levels in granulosa cells (GC) and its
subsequent effect on fertilization are limited. Oxidative stress (OS) mediated alterations in …

Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

Limited knowledge exists about changes in follicle quality associated with age. The aim of
this work was to investigate whether ageing may cause oxidative stress-mediated alterations …

Basic scientific research on human reproduction and oxidative damage has been
extensively performed; however, a more clinical view is still lacking. As a result, exhaustive …

In a healthy body, reactive oxygen species (ROS) and antioxidants remain balanced. When
the balance is broken toward an overabundance of ROS, oxidative stress appears and may …

Ovarian aging is a long-term and complex process associated with a decrease in follicular
quantity and quality. The damaging effects of reactive oxygen species (ROS) in ovarian …

Oxidative stress has been implicated in various aspects of aging, but the role of oxidative
stress in ovarian aging remains unclear. Our previous studies have shown that the initiation …

The age at which women have their first child is increasing. This change represents a major
health problem to society because advanced maternal age is related with a decay in fertility …