We found that the selective stimulation of the intracellular, transmembrane G protein–
coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure …

Endogenous estrogens are important regulators of cardiovascular homeostasis in
premenopausal women and delay the development of hypertension and coronary artery …

The G protein-coupled estrogen receptor (GPER) is a 7-transmembrane receptor implicated
in rapid estrogen signaling. Originally cloned from vascular endothelial cells, GPER plays a …

The mRen2. Lewis congenic strain is an estrogen-sensitive model of hypertension whereby
estrogen depletion produces a significant and sustained increase in blood pressure. The …

Estrogens can either relax or contract arteries via rapid, nongenomic mechanisms involving
classic estrogen receptors (ER). In addition to ERα and ERβ, estrogen may also stimulate G …

Estrogens play a critical role in many aspects of physiology, particularly female reproductive
function, but also in pathophysiology, and are associated with protection from numerous …

Metabolic homeostasis is differentially regulated in males and females. The lower incidence
of obesity and associated diseases in pre-menopausal females points towards the beneficial …

Coronary atherosclerosis and myocardial infarction in postmenopausal women have been
linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts …

Our studies in the mRen2. Lewis female rat, an angiotensin II-and estrogen-dependent
model of hypertension, revealed that chronic activation of estrogen receptor GPR30 …

The recent discovery of the G protein-coupled estrogen receptor (GPER) presents new
challenges and opportunities for understanding the physiology, pathophysiology, and …