Gout is a chronic disease caused by monosodium urate (MSU) crystal deposition. Gout
typically presents as an acute, self-limiting inflammatory monoarthritis that affects the joints …

Gout is a metabolic disease caused by the deposition of monosodium urate (MSU) crystals
inside joints, which leads to inflammation and tissue damage. Increased concentration of …

Gout is a disease in which the metabolic condition hyperuricemia leads to the formation of
monosodium urate crystals, which provoke acute and chronic inflammatory responses …

In most mammals purine degradation ultimately leads to the formation of allantoin. Humans
lack the enzyme uricase, which catalyzes the conversion of uric acid to allantoin. The …

Hyperuricemia with consequent monosodium urate crystal deposition leads to gout,
characterized by painful, incapacitating inflammatory arthritis flares that are also associated …

Objectives Allopurinol is the most widely prescribed serum uric acid-lowering therapy (ULT)
in gout. To achieve serum uric acid (sUA) concentrations associated with clinical benefit …

Acute gout attacks and the long-term complications of gout are associated with the
deposition of monosodium urate (MSU) monohydrate crystals in the joints and soft tissues …

Uric acid is a waste product of purine catabolism. This molecule comes to clinical attention
when it nucleates to form crystals of monosodium urate (MSU) in joints or other tissues, and …

Background The relative efficacy and safety of allopurinol and febuxostat when used
according to current guidelines for the treatment of hyperuricemia are unknown. This double …

Gout is the most common inflammatory arthritis worldwide. Although effective treatments
exist to eliminate sodium urate crystals and to'cure'the disease, the management of gout is …