Necroptotic cell binding of β2‐glycoprotein I provides a potential autoantigenic stimulus in systemic lupus erythematosus
D Salem, R Subang, E Pernet… - … and Cell Biology, 2019 - Wiley Online Library
Systemic lupus erythematosus (SLE) is characterized by the development of autoantibodies
against diverse self‐antigens with damage to multiple organs. Immunization with the SLE …
against diverse self‐antigens with damage to multiple organs. Immunization with the SLE …
The Src family kinases Hck, Fgr, and Lyn are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment
Although Src family kinases participate in leukocyte function in vitro, such as integrin signal
transduction, their role in inflammation in vivo is poorly understood. We show that Src family …
transduction, their role in inflammation in vivo is poorly understood. We show that Src family …
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease
MJ Maxwell, E Tsantikos, AM Kong… - Journal of …, 2012 - Elsevier
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease
characterized by the production of autoantibodies against nuclear components. Lyn …
characterized by the production of autoantibodies against nuclear components. Lyn …
[PDF][PDF] The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation
T cell activation is tightly regulated to avoid autoimmunity. Gene related to anergy in
lymphocytes (GRAIL, encoded by Rnf128) is an E3 ubiquitin ligase associated with T cell …
lymphocytes (GRAIL, encoded by Rnf128) is an E3 ubiquitin ligase associated with T cell …
Differential requirement for RhoH in development of TCRαβ CD8αα IELs and other types of T cells
H Oda, N Tamehiro, MS Patrick, K Hayakawa… - Immunology letters, 2013 - Elsevier
RhoH is a new member of the atypical G proteins exclusively expressed in hematopoietic
lineage cells. It has been shown to act as an adaptor for ZAP70, Syk, Lck and Csk kinases in …
lineage cells. It has been shown to act as an adaptor for ZAP70, Syk, Lck and Csk kinases in …
Natural IgM anti-leucocyte autoantibodies (IgM-ALA) regulate inflammation induced by innate and adaptive immune mechanisms
PI Lobo, KL Brayman, MD Okusa - Journal of clinical immunology, 2014 - Springer
Little is known about the function of natural IgM autoantibodies, especially that of IgM anti-
leukocyte autoantibodies (IgM-ALA). Natural IgM-ALA are present at birth and …
leukocyte autoantibodies (IgM-ALA). Natural IgM-ALA are present at birth and …
Role of RANTES in the development of autoimmune tissue injuries in MRL-Fas lpr mice
T Tsukahara, Y Makino, T Fujii, M Ogawa, H Saisho… - Clinical …, 2002 - Elsevier
MRL-Fas lpr mice spontaneously develop a severe autoimmune disease closely resembling
human SLE. To investigate the possible role of RANTES in autoimmune tissue injuries, we …
human SLE. To investigate the possible role of RANTES in autoimmune tissue injuries, we …
[HTML][HTML] Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B …
K Csomos, B Ujhazi, P Blazso, JL Herrera… - Nature …, 2022 - nature.com
The recombination-activating genes (RAG) 1 and 2 are indispensable for diversifying the
primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the …
primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the …
Immunological phenotype of the murine Lrba knockout
L Gámez‐Díaz, J Neumann, F Jäger… - Immunology and cell …, 2017 - Wiley Online Library
Biallelic mutations in the human lipopolysaccharide responsive beige‐like anchor (LRBA)
gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a …
gene lead to a primary immunodeficiency known as LRBA deficiency, characterized by a …
[HTML][HTML] Paradoxical Effects of All-Trans-Retinoic Acid on Lupus-Like Disease in the MRL/lpr Mouse Model
Roles of all-trans-retinoic acid (tRA), a metabolite of vitamin A (VA), in both tolerogenic and
immunogenic responses are documented. However, how tRA affects the development of …
immunogenic responses are documented. However, how tRA affects the development of …