Prevalence and health consequences of obesity differ between men and women. Yet, most
preclinical studies investigating the etiology of obesity have, to date, been conducted in …

Abstract Background/Objective Female mice are often excluded from diet-induced obesity
studies as they are more resistant to the obesifying effects of a high-fat diet (HFD). However …

Background Obesity and the metabolic syndrome are increasingly prevalent in society and
their complications and response to treatment exhibit sexual dimorphism. Mouse models of …

Aims The present study aims to compare the responses between male and female C57BL/6
mice to multiple metabolic challenges to understand the importance of sex in the control of …

Background Consumption of high-fat diet (HF) leads to hyperphagia and increased body
weight in male rodents. Female rodents are relatively resistant to hyperphagia and weight …

Background: Metabolic disorders are commonly investigated using knockout and transgenic
mouse models on the C57BL/6N genetic background due to its genetic susceptibility to the …

Objective: Adverse effects of obesity on glucose homeostasis are linked to low-grade
adipose tissue inflammation and accumulation of lipids in non-adipose tissues. The goal of …

Sex differences in obesity-induced complications such as type 2 diabetes have been
reported. The aim of the study was to pinpoint the mechanisms resulting in different outcome …

Objective To investigate the variations in body weight, food intake, and body composition of
both male and female C57BL/6J mice during a diet‐induced obesity model with high‐fat diet …

Social and psychological factors interact with genetic predisposition and dietary habit in
determining obesity. However, relatively few pre-clinical studies address the role of …