Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) remain
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …
without effective therapies. The mechanistic target of rapamycin complex 1 (mTORC1) …
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing
The multi-component mechanistic target of rapamycin complex 1 (mTORC1) kinase is the
central node of a mammalian pathway that coordinates cell growth with the availability of …
central node of a mammalian pathway that coordinates cell growth with the availability of …
[HTML][HTML] Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways
Through unknown mechanisms, insulin activates the sterol regulatory element-binding
protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that this …
protein (SREBP1c) transcription factor to promote hepatic lipogenesis. We find that this …
[HTML][HTML] Liver damage, inflammation, and enhanced tumorigenesis after persistent mTORC1 inhibition
Obesity can result in insulin resistance, hepatosteatosis, and nonalcoholic steatohepatitis
(NASH) and increases liver cancer risk. Obesity-induced insulin resistance depends, in part …
(NASH) and increases liver cancer risk. Obesity-induced insulin resistance depends, in part …
[HTML][HTML] Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver
Summary mTOR and ERRα are key regulators of common metabolic processes, including
lipid homeostasis. However, it is currently unknown whether these factors cooperate in the …
lipid homeostasis. However, it is currently unknown whether these factors cooperate in the …
[PDF][PDF] Fructose leads to hepatic steatosis in zebrafish that is reversed by mechanistic target of rapamycin (mTOR) inhibition
V Sapp, L Gaffney, SF EauClaire, RP Matthews - Hepatology, 2014 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD), the accumulation of lipid within hepatocytes, is
increasing in prevalence. Increasing fructose consumption correlates with this increased …
increasing in prevalence. Increasing fructose consumption correlates with this increased …
mTORC1 activity repression by late endosomal phosphatidylinositol 3, 4-bisphosphate
Nutrient sensing by mechanistic target of rapamycin complex 1 (mTORC1) on lysosomes
and late endosomes (LyLEs) regulates cell growth. Many factors stimulate mTORC1 activity …
and late endosomes (LyLEs) regulates cell growth. Many factors stimulate mTORC1 activity …
Connecting mTORC1 signaling to SREBP-1 activation
I Bakan, M Laplante - Current opinion in lipidology, 2012 - journals.lww.com
The discovery of a connection between mTORC1 and SREBP-1 opens a new chapter in our
understanding of the molecular mechanisms regulating de-novo lipogenesis. A better …
understanding of the molecular mechanisms regulating de-novo lipogenesis. A better …
mTORC1 signaling in hepatic lipid metabolism
J Han, Y Wang - Protein & cell, 2018 - academic.oup.com
The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic
and physiological processes in different organs or tissues. Dysregulation of mTOR signaling …
and physiological processes in different organs or tissues. Dysregulation of mTOR signaling …
mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
M Laplante, DM Sabatini - Proceedings of the National …, 2010 - National Acad Sciences
Insulin resistance, which is defined as the inability of insulin to promote efficient glucose
uptake by peripheral tissues, is a metabolic condition associated with obesity, type 2 …
uptake by peripheral tissues, is a metabolic condition associated with obesity, type 2 …