We report the isolation of b&x, a b&2-related gene that can function as a bcl-24ndependent
regulator of programed ceil death (apoptosis). Alternative splicing results in two distinct b&x …

The bcl‐2 gene product, a 25 kDa membrane protein residing at mitochondrial, microsomal
and nuclear membrane sites within many cell types, is a broad and potent inhibitor of cell …

Bcl‐x L, a member of the Bcl‐2 family, can inhibit many forms of programed cell death. The
three‐dimensional structure of Bcl‐x L identified a 60 amino acid loop lacking defined …

A novel oncogene-derived protein, Bcl-2, functions as a repressor of cell death in a genetic
pathway of cellular suicide that appears to be common to all multicellular animals. A related …

HE terms programmed cell death (PCD) 1 and apoptosis are often used interchangeably to
describe a mechanism of cellular demise that is believed to play an important role in a wide …

Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the
mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We …

The BCL-2 gene was identified at the chromosomal breakpoint of t (14; 18)-bearing human
follicular B cell lymphomas. BCL-2 proved to block programmed cell death rather than …

The Bcl‐2 family of proteins regulate apoptosis, some antagonizing cell death and others
facilitating it. It has recently been demonstrated that Bcl‐2 not only inhibits apoptosis but also …

The bcl‐2 gene has a unique function among mammalian oncogenes as a negative
regulator of apoptosis. Its expression pattern in embryonic and adult tissues is consistent …

Overexpression of the cytoplasmic oncoprotein Bcl2 blocks programmed cell death
(apoptosis) in many cellular systems. To map the sequences in Bcl2 that are necessary for …