Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus etiologically causal
of adult T-cell leukemia (ATL). ATL is a highly virulent cancer that is resistant to …

The recent discovery of HBZ, an antisense protein, encoded by HTLV-1 allowed a new way
of understanding how HTLV-1 induces the development of adult T cell leukemia/lymphoma …

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered.
Studies on HTLV-1 have been instrumental for our understanding of the molecular …

Since the identification of the antisense protein of HTLV-2 (APH-2) and the demonstration
that APH-2 mRNA is expressed in vivo in most HTLV-2 carriers, much effort has been …

We recently discovered the antisense protein of human T-cell leukemia virus (HTLV) type 2
(APH-2), whose messenger RNA is encoded by the antisense strand of the HTLV-2 genome …

Background The antisense transcript-encoded HBZ protein acts upon viral and cellular gene
expression through its modulation of the activation of transcription factors such as Jun family …

Background In this study, we have examined the role of heterogeneous nuclear
ribonucleoprotein A1 (hnRNP A1) in viral gene expression in T lymphocytes transformed by …

During HTLV-1 gene expression, positive transcription elongation factor b (pTEFb) is
recruited to the long terminal repeat by Tax. Usually, additional proteins and elongation …

Thetatgene product of the human immunodeficiency virus type 1 (HIV-1) strongly induces
the transcription directed by the viral long terminal repeat (LTR). Tat acts by interacting with …

Background Plants remain an important source of new drugs, new leads and new chemical
entities. Triptolide is a diterpenoid epoxide isolated from Tripterygium wilfordii Hook F that …