Objectives The HTLV-1 accessory protein p8 is a plasma membrane-resident protein that
induces cellular protrusions through which both p8 and HTLV-1 are transferred to target …

Human T-lymphotropic virus type 1 (HTLV-1) is a causative agent of adult T cell
leukemia/lymphoma and a variety of inflammatory disorders. HTLV-1 encodes a nuclear …

Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are known to interact
with several transcription factors and regulate their transcriptional activities. The human T …

The TAR DNA binding protein (TDP-43) was originally identified as a host cell factor binding
to the HIV-1 LTR and thereby suppressing HIV-1 transcription and gene expression (Ou et …

The innate ability of the human cell to silence endogenous retroviruses through RNA
sequences encoding micro-RNAs, suggests that the cellular RNAi machinery is a major …

Approximately 8% of the human genome is made up of endogenous retroviral sequences.
As the HIV-1 Tat protein activates the overall expression of the human endogenous …

HTLV-1 cellular transformation and disease induction is dependent on expression of the
viral Tax oncoprotein. PDZ is a modular protein interaction domain used in organizing …

The positive transcription elongation factor b (P-TEFb) is an essential factor that induces
transcription elongation and is also negatively regulated by the cellular factor HEXIM1 …

The molecular mechanisms involved in the regulation of human immunodeficiency virus
type 1 (HIV-1) replication may differ in various cell types and with various exogenous stimuli …

Human T cell leukemia virus type 1 (HTLV-1) Tax protein transforms primary human T cells
in vitro. We previously showed that Tax induces the expression of various family members of …