P2Y receptor‐mediated Ca2+ signalling in cultured rat aortic smooth muscle cells

JD Pediani, JC McGrath… - British journal of …, 1999 - Wiley Online Library
ATP, UTP, ADP and ADP‐β‐S elicited Ca2+‐signals in cultured aortic smooth muscle cells
although ADP, UDP and ADP‐β‐S gave∼ 40% of the maximal response seen with ATP and …

Analysis of purine-and pyrimidine-induced vascular responses in the isolated rat cerebral arteriole

T Horiuchi, HH Dietrich, S Tsugane… - American Journal of …, 2001 - journals.physiology.org
Effects of extraluminal UTP were studied and compared with vascular responses to ATP and
its analogs in rat cerebral-penetrating arterioles. UTP, UDP, 2-methylthio-ATP, and α, β …

P2U‐receptor mediated endothelium‐dependent but nitric oxide‐independent vascular relaxation

M Malmsjö, L Edvinsson… - British journal of …, 1998 - Wiley Online Library
The dilator effect of extracellular adenosine triphosphate (ATP) has mainly been
characterized as a direct effect on smooth muscle or as an endothelium‐dependent effect …

Evidence that most high-affinity ATP binding sites on aortic endothelial cells and membranes do not correspond to P2 receptors

S Motte, S Swillens, JM Boeynaems - European journal of pharmacology, 1996 - Elsevier
It has recently been demonstrated that two types of ATP receptors, the P2y and P2u
receptors, are coexpressed on bovine aortic endothelial cells. The aim of the present study …

UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors

M Hou, TK Harden, CM Kuhn… - American Journal …, 2002 - journals.physiology.org
Mitogenic effects of the extracellular nucleotides ATP and UTP are mediated by P2Y1, P2Y2,
and P2Y4 receptors. However, it has not been possible to examine the highly expressed …

Ca2+ signalling by P2Y receptors in cultured rat aortic smooth muscle cells

S Govindan, EJA Taylor… - British journal of …, 2010 - Wiley Online Library
Background and purpose: P2Y receptors evoke Ca2+ signals in vascular smooth muscle
cells and regulate contraction and proliferation, but the roles of the different P2Y receptor …

Extracellular ATP Induces Vascular Inflammation and Atherosclerosis via Purinergic Receptor Y2 in Mice

P Stachon, S Geis, A Peikert… - … and Vascular Biology, 2016 - Am Heart Assoc
Objective—A solid body of evidence supports a role of extracellular ATP and its P2 receptors
in innate and adaptive immunity. It promotes inflammation as a danger signal in various …

[HTML][HTML] Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179

RA Kaiser, ILO Buxton - British journal of pharmacology, 2002 - ncbi.nlm.nih.gov
Nucleotide-mediated relaxation in guinea-pig aorta: selective inhibition by MRS2179 - PMC
Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

UTP induces vascular responses in the isolated and perfused canine epicardial coronary artery via UTP‐preferring P2Y receptors

T Matsumoto, T Nakane, S Chiba - British journal of …, 1997 - Wiley Online Library
1 Vasoconstrictor responses of the isolated and perfused canine epicardial coronary artery
to uridine 5′‐triphosphate (UTP) were analysed pharmacologically. 2 At basal perfusion …

P2Y receptor‐induced EDHF vasodilatation is of primary importance for the regulation of perfusion pressure in the peripheral circulation of the rat

M Malmsjö, ZM Chu, K Croft, D Erlinge… - Acta physiologica …, 2002 - Wiley Online Library
Extracellular nucleotides have been shown to induce vasodilatation of conductance arteries
by release of the endothelium‐derived hyperpolarizing factor (EDHF). As small resistance …