Aging has a remarkable effect on cardiovascular homeostasis and it is known as the major
non-modifiable risk factor in the development of hypertension. Medications targeting …

Adenosine‐5′‐triphosphate (ATP) is a potent coronary vasodilator. Because of the efficient
hydrolysis of ATP, adenosine‐5′‐diphosphate (ADP) and adenosine‐5′‐monophosphate …

P2 receptor mediated contractile responses have been characterized in different diameter
arteries from the rat mesenteric arterial vasculature (first, second to third and fifth to sixth …

Abstract ATP (EC 50 5 μM) induced endothelium-dependent relaxation of the isolated aorta
of the newborn pig, but the other naturally occurring nucleotides CTP, GTP, ITP and UTP …

The hypothesis that ATP and ADP produce dilations of rat middle cerebral arteries (MCAs)
by different mechanisms was tested. Vessel diameters were measured from pressurized …

Activation of ADP-sensitive P2Y1 receptors has been proposed as an integral step in the
putative “nucleotide axis” regulating coronary blood flow. However, the specific mechanism …

1 The main aim of this study was to characterize the antagonistic effects of
pyridoxalphosphate‐6‐azophenyl‐2′, 4′‐disulphonic acid (PPADS) at coexisting …

Background—Extracellular uridine 5′-triphosphate (UTP) induces mitogenic activation of
smooth muscle cells (SMCs) through binding to P2Y2 nucleotide receptors. P2Y2 receptor …

1 Purine and pyrimidine nucleotides evoke changes in the vascular tone of medium to large
cerebral vessels through the activation of P2 purinoceptors. We have applied P2 receptor …

Uridine nucleotides are known to cause constriction of pulmonary arterial smooth muscle.
However, the P2 receptor subtypes underlying the contractile effects of these nucleotides in …