Studies have shown that microRNA-148a (miR-148a) was proved to be silenced while DNA
methyltransferase 1 (DNMT1) was over-expressed in gastric cancer. But the mechanism of …

Background MicroRNAs are associated with tumor genesis and progression in various
carcinomas. MicroRNA-148a (miR-148a) was reported to have low expression in …

Abstract miRNAs have emerged as crucial regulators in the regulation of development as
well as human diseases, especially tumorigenesis. The aims of this study are to evaluate …

The dysregulation of microRNA expression is significantly associated with the initiation and
development of CRC. miR-124 is markedly downregulated in colorectal cancer. In the …

DNA methylation is an epigenetic mechanism that cells use to control gene expression,
which serves an important role in tumorigenesis. DNA methyltransferase 1 (DNMT1) is …

Overexpression of DNA methyltransferase 1 (DNMT-1) is observed mostly in pancreatic
cancer and it can cause tumor suppressor genes silencing in this disease. Recent studies …

Background MicroRNAs act as posttranscriptional regulators of gene expression in many
biological processes. Their deregulations occur commonly in gastric cancer (GC). Although …

Overexpressed DNA methyltransferase 1 (DNMT1) strongly contributes to tumor suppressor
gene silencing in colorectal cancer (CRC). However, the underlying mechanism of DNMT1 …

Aim: To identify whether miR-148a-3p interacts with DNA (cytosine-5)-methyltransferase 1
(DNMT1) in esophageal cancer. Methods: A luciferase assay and immunoblotting were …

MicroRNAs (miRNAs) are small non-protein-coding RNAs that regulate expression of a wide
variety of genes including those involved in cancer development. Here, we investigate the …