Advances in lymphatic imaging and drug delivery

SK Nune, P Gunda, BK Majeti, PK Thallapally… - Advanced drug delivery …, 2011 - Elsevier
Cancer remains the second leading cause of death after heart disease in the US. While
metastasized cancers such as breast, prostate, and colon are incurable, before their distant …

Dynamic imaging of lymphatic vessels and lymph nodes using a bimodal nanoparticulate contrast agent

R Mounzer, P Shkarin, X Papademetris… - Lymphatic Research …, 2007 - liebertpub.com
Background: Evaluation of lymphedema and lymph node metastasis in humans has relied
primarily on invasive or radioactive modalities. While noninvasive technologies such as …

Lymphatic targeting for therapeutic application using nanoparticulate systems

N Singh, M Handa, V Singh, P Kesharwani… - Journal of Drug …, 2022 - Taylor & Francis
The lymphatic system has grasped attention of researchers to a greater extent. The
conventional methods of lymphatic delivery are now being modified to include …

Lymph node metastases: importance of detection and treatment strategies

A Obinu, E Gavini, G Rassu, M Maestri… - Expert opinion on …, 2018 - Taylor & Francis
Introduction: Lymphatic vessels are the preferential route of most solid tumors to spread their
metastases in the body. The onset of metastatic nests in draining lymph nodes (LNs) are a …

Revolutionizing lymph node metastasis imaging: the role of drug delivery systems and future perspectives

ZM Cai, ZZ Li, NN Zhong, LM Cao, Y Xiao, JQ Li… - Journal of …, 2024 - Springer
The deployment of imaging examinations has evolved into a robust approach for the
diagnosis of lymph node metastasis (LNM). The advancement of technology, coupled with …

Drug delivery to the lymphatic system: importance in future cancer diagnosis and therapies

Y Xie, TR Bagby, MS Cohen… - Expert opinion on drug …, 2009 - Taylor & Francis
Cancer is the second leading cause of death in the US. Currently, protocols for cancer
treatment include surgery to remove diseased and suspect tissues, focused radiation …

Lymphatic changes in cancer and drug delivery to the lymphatics in solid tumors

B Cote, D Rao, RG Alany, GS Kwon… - Advanced Drug Delivery …, 2019 - Elsevier
Although many solid tumors use the lymphatic system to metastasize, there are few
treatment options that directly target cancer present in the lymphatic system, and those that …

Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

D Olmeda, D Cerezo-Wallis, E Castellano-Sanz… - Advanced Drug Delivery …, 2021 - Elsevier
Imaging of the lymphatic vasculature has gained great attention in various fields, not only
because lymphatic vessels act as a key draining system in the body, but also for their …

Subcutaneous and intravenous delivery of diagnostic agents to the lymphatic system: applications in lymphoscintigraphy and indirect lymphography

SM Moghimi, B Bonnemain - Advanced drug delivery reviews, 1999 - Elsevier
Lymph node status is important in the staging of many malignancies. Although tissue
characterization by histologic analysis of biopsy samples may improve staging, noninvasive …

Nanoparticles for lymph node-directed delivery

J Lee, S Kang, H Park, JG Sun, EC Kim, G Shim - Pharmaceutics, 2023 - mdpi.com
Lymph nodes are organs that control immune cells and provide a major pathway for primary
tumors to metastasize. A nanoparticles-based strategy has several advantages that make it …