Objective: The definition of normal adrenal function in critically ill patients remains
controversial, despite a large body of literature. We review the clinical presentation …

Adequate adrenocortical function is essential to survive critical illness. Most critically ill
patients display an elevated plasma cortisol level, reflecting activation of the pituitary …

Objective To present a recommended approach to the problem of “relative” adrenal
insufficiency (RAI) in the intensive care unit (ICU). Methods We examine historical data that …

Objective: To review current concepts in the diagnosis of adrenocortical disease in the
critically ill patient. Data sources: A review of articles reported on adrenocortical insufficiency …

Critically ill patients may develop glucocorticoid insufficiency at some stage. It encompasses
a decrease in glucocorticoid synthesis (ie, adrenal insufficiency) and peripheral resistance …

Objective To compare the total plasma cortisol values obtained from three widely used
immunoassays and a high pressure liquid chromatography (HPLC) technique on samples …

Objective One of the most common dynamic testing procedures for assessment of
adrenocortical function is the standard corticotropin or the cosyntropin test. The aim of this …

Purpose To study the value of free versus total cortisol levels in assessing relative adrenal
insufficiency during critical illness-related corticosteroid insufficiency. Methods A prospective …

The definition of what constitutes a'normal'adrenal response to critical illness is unclear.
Consequently, published studies have used a variety of biochemical criteria to …

The reported incidence of adrenal insufficiency varies greatly depending on the population
of critically ill patients studied, the test and cutoff levels used, and the severity of illness …