Nebivolol: A Third-Generation β-Blocker That Augments Vascular Nitric Oxide Release: Endothelial β2-Adrenergic Receptor–Mediated Nitric Oxide Production

MAW Broeders, PA Doevendans, BCAM Bekkers… - Circulation, 2000 - Am Heart Assoc
Background—Nebivolol is a β1-selective adrenergic receptor antagonist with proposed nitric
oxide (NO)–mediated vasodilating properties in humans. In this study, we explored whether …

Nebivolol induces nitric oxide release in the heart through inducible nitric oxide synthase activation

A Maffei, A Di Pardo, R Carangi, P Carullo, R Poulet… - …, 2007 - Am Heart Assoc
Nebivolol is a β1-adrenergic receptor antagonist that also reduces blood pressure by
evoking endothelial NO production and vasodilation. We aimed at assessing whether …

Characterization of nitric oxide release by nebivolol and its metabolites

A Maffei, C Vecchione, A Aretini… - American journal of …, 2006 - academic.oup.com
Background: Nebivolol is a selective β1-adrenergic receptor antagonist that causes a direct
vasodilator effect attributed to the action on vascular nitric oxide (NO). This study aimed to …

Nebivolol: A Highly Selective β1‐Adrenergic Receptor Blocker That Causes Vasodilation by Increasing Nitric Oxide

S Gupta, HM Wright - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol (Bystolic®) is a cardioselective beta 1 (β1)‐adrenergic receptor blocker with
endothelium‐dependent vasodilating properties. The endothelium‐dependent relaxation …

Experimental evidences of nitric oxide‐dependent vasodilatory activity of nebivolol, a third‐generation β‐blocker

L Ignarro - Blood Pressure, 2004 - Taylor & Francis
Nebivolol is a new and selective β 1‐adrenergic receptor antagonist whose haemodynamic
profile is different from that of classical β‐blockers. The blood pressure lowering effects of …

Mechanisms underlying nebivolol‐induced endothelial nitric oxide synthase activation in human umbilical vein endothelial cells

D Ladage, K Brixius, H Hoyer… - Clinical and …, 2006 - Wiley Online Library
SUMMARY 1 Nebivolol (NEB) has been shown to be a selective blocker of β1‐
adrenoceptors with additional vasodilating properties that are mediated, at least in part, by …

Endothelial β3-Adrenoreceptors Mediate Nitric Oxide–Dependent Vasorelaxation of Coronary Microvessels in Response to the Third-Generation β-Blocker Nebivolol

C Dessy, J Saliez, P Ghisdal, G Daneau, II Lobysheva… - Circulation, 2005 - Am Heart Assoc
Background—The therapeutic effects of nonspecific β-blockers are limited by
vasoconstriction, thus justifying the interest in molecules with ancillary vasodilating …

Involvement of the β3 adrenoceptor in nebivolol-induced vasorelaxation in the rat aorta

AA de Groot, MJ Mathy, PA van Zwieten… - Journal of …, 2003 - journals.lww.com
Nebivolol is a highly selective β 1 adrenoceptor blocker with additional vasodilating
properties. Although it has been shown that the nebivolol-induced vasorelaxation is nitric …

Nitric oxide mechanisms of nebivolol

A Maffei, G Lembo - Therapeutic advances in cardiovascular …, 2009 - journals.sagepub.com
β-blockers are among the most widely used drugs in the prevention and treatment of
cardiovascular disease, although they are associated with increased peripheral resistance …

Different pharmacological properties of two enantiomers in a unique β‐blocker, nebivolol

LJ Ignarro - Cardiovascular therapeutics, 2008 - Wiley Online Library
Nebivolol is a racemic combination of d‐nebivolol (+ SRRR nebivolol) and l‐nebivolol (–
RSSS nebivolol) that differs chemically from other β‐blockers, with an absolutely …