[HTML][HTML] The glymphatic system (en) during inflammation

FLH Mogensen, C Delle, M Nedergaard - International journal of …, 2021 - mdpi.com
The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

[HTML][HTML] Glymphatic system: an emerging therapeutic approach for neurological disorders

Y Gao, K Liu, J Zhu - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
The functions of the glymphatic system include clearance of the metabolic waste and
modulation of the water transport in the brain, and it forms a brain-wide fluid network along …

[HTML][HTML] The glymphatic system: a new perspective on brain diseases

Z Ding, X Fan, Y Zhang, M Yao, G Wang… - Frontiers in Aging …, 2023 - frontiersin.org
The glymphatic system is a brain-wide perivascular pathway driven by aquaporin-4 on the
endfeet of astrocytes, which can deliver nutrients and active substances to the brain …

The glymphatic system in central nervous system health and disease: past, present, and future

BA Plog, M Nedergaard - Annual Review of Pathology …, 2018 - annualreviews.org
The central nervous system (CNS) is unique in being the only organ system lacking
lymphatic vessels to assist in the removal of interstitial metabolic waste products. Recent …

A clinical primer for the glymphatic system

LP Carlstrom, A Eltanahy, A Perry, AA Rabinstein… - Brain, 2022 - academic.oup.com
The complex and dynamic system of fluid flow through the perivascular and interstitial
spaces of the CNS has new-found implications for neurological diseases. CSF movement …

The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

[HTML][HTML] Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

A Louveau, BA Plog, S Antila, K Alitalo… - The Journal of …, 2017 - Am Soc Clin Investig
Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have
generated a lot of excitement, along with some degree of skepticism. Here, we summarize …

[HTML][HTML] The glymphatic system: a novel therapeutic target for stroke treatment

T Lv, B Zhao, Q Hu, X Zhang - Frontiers in Aging Neuroscience, 2021 - frontiersin.org
The glymphatic system (GS) is a novel defined brain-wide perivascular transit network
between cerebrospinal fluid (CSF) and interstitial solutes that facilitates the clearance of …

[HTML][HTML] CNS-draining meningeal lymphatic vasculature: roles, conundrums and future challenges

SP das Neves, N Delivanoglou… - Frontiers in …, 2021 - frontiersin.org
A genuine and functional lymphatic vascular system is found in the meninges that sheath the
central nervous system (CNS). This unexpected (re) discovery led to a reevaluation of CNS …

[HTML][HTML] Glymphatic system as a gateway to connect neurodegeneration from periphery to CNS

G Natale, F Limanaqi, CL Busceti… - Frontiers in …, 2021 - frontiersin.org
The classic concept of the absence of lymphatic vessels in the central nervous system
(CNS), suggesting the immune privilege of the brain in spite of its high metabolic rate, was …