SIRT6 is a member of the sirtuin family of class III histone deacetylases. It plays important
roles in regulating genomic stability, metabolism, stress response and aging. Our previous …

BACKGROUND AND PURPOSE Sirtuin 6 (SIRT6) is involved in regulation of glucose and
fat metabolism. However, its possible contribution to cardiac dysfunction remains to be …

Abstract Sirtuin 3 (SIRT3) is a type III histone deacetylase that inhibits cardiac hypertrophy. It
is mainly localized in the mitochondria and is thus implicated in mitochondrial metabolism …

Abstract Sirtuin3 (SIRT3), a class III histone deacetylase, is implicated in various
cardiovascular diseases as a novel therapeutic target. SIRT3 has been proven to be …

The sirtuin SIRT1 is an ubiquitous NAD+ dependent deacetylase that plays a role in
biological processes such as longevity and stress response. In cardiac models, SIRT1 is …

The activation of signal transducer and activator of transcription 3 (STAT3) is critical for the
development of cardiac hypertrophy and heart failure. Sirtuin 6 (SIRT6) protects …

Abstract Sirtuin 3 (SIRT3) is a deacetylase that modulates proteins that control metabolism
and protects against oxidative stress. Modulation of SIRT3 activity has been proposed as a …

Heart failure (HF) represents the most common endpoint of most cardiovascular diseases
(CVDs) which are the leading causes of death around the world. Despite the advances in …

Sirt (Sirtuin) 7, the most recently identified mammalian sirtuin, has been shown to contribute
to appropriate wound healing processes after acute cardiovascular insult. However, its role …

Sirtuins (SIRT) exhibit deacetylation or ADP-ribosyltransferase activity and regulate a wide
range of cellular processes in the nucleus, mitochondria, and cytoplasm. The role of the only …