Interleukin‐6 (IL‐6) is a classic pro‐inflammatory cytokine critical in mounting an effective
immune response. It is secreted by a wide array of cell types; however, its effector cells are …

Interleukin‐6 is currently attracting significant interest as a potential therapeutic target in
systemic sclerosis (SSc). In this paper, the biology of interleukin‐6 is reviewed, and the …

Objective. The purpose of this study was to review the potential importance of interleukin 6
(IL-6) in systemic sclerosis (SSc). Methods. PubMed and Scopus databases and American …

Systemic sclerosis (SSc) is a chronic multisystem disorder characterized by fibrosis and
autoimmunity. Interleukin (IL)-31 has been implicated in fibrosis and T helper (Th) 2 immune …

Interleukin-6 is a classic pro-inflammatory cytokine needed to mount an effective immune
response. It is secreted by a wide array of cell types, however, its target cells are more …

Chronic inflammation can lead to altered extracellular matrix deposition and ultimately
fibrosis. Interleukin‐13 (IL‐13) is a cytokine that was found to promote IgE class switching …

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and
internal organs. Its pathogenesis, which is still poorly understood, features three main …

Objective To determine the potential clinical and pathological significance of altered
expression of interleukin 6 (IL-6) in systemic sclerosis (SSc). Methods Serum IL-6 and …

The fundamental mechanisms that drive the pathogenesis of systemic sclerosis (SSc)
remain elusive, despite over 50 years of investigation. Here, we review recent progress in …

Interleukin (IL)‐6 is a multifunctional cytokine that regulates immune response, inflammation,
and hematopoiesis. Although IL‐6 plays several important physiological roles, deregulated …