The mammalian gene encoding the α subunit of the Go protein generates by alternative
splicing two isoforms, αo1 and αo2, which differ in their carboxy-terminal region. We report …

Heterotrimeric G proteins play an essential role in coupling numerous surface membrane
receptors to intracellular signal transduction pathways. Relatively little is known about the …

We screened a HIT (hamster insulin-secreting tumor) cell cDNA library constructed in
lambda gt11 with a Go-specific oligonucleotide probe and isolated six recombinant phages …

We have previously identified two isoforms of Go alpha in membranes of N1E-115
neuroblastoma cells, using an antibody raised against the purified Go alpha subunit; one …

Northern analysis shows that G o α mRNA is highly expressed in immature germ cells from
rat. Whereas α o2 mRNA is the major form in pachytene spermatocytes, a message of …

Hybridization blot (Northern) analysis of mRNA coding for alpha subunits of the Go signal-
transducing protein detects three bands at 5.7, 4.2, and 3.2 kilobases (kb). We showed …

The α subunits of heterotrimeric G proteins are responsible for the coupling of receptors for a
wide variety of stimuli to a number of intracellular effector systems. In the nervous system of …

A Go type G protein distinct from the major species of Go was recently isolated from bovine
brain and designated Go*. The cDNAs encoding two forms of mammalian Goα were also …

G o is the major G protein in bovine brain, with at least three isoforms, G oA, G oB, and G oC.
Whereas α oA and α oB arise from a single G o α gene as alternatively spliced mRNAs, α oA …

We have previously shown that undifferentiated N1E-115 neuroblastoma cells express only
one isoform of Go alpha (pI= 5.8), whereas differentiated neuroblastoma cells expressed, in …