In fish, the knowledge on the regulation of inflammatory responses is limited. In the present
study, LPS rapidly increased the mRNA levels of grass carp pro-inflammatory factors …

Abstract Interleukin-1β (IL-1β) is a well-characterized cytokine that plays key roles in cellular
responses to infection, inflammation, and immunological challenges in mammals. In this …

In the present study, we found that recombinant grass carp IL-1β (rgcIL-1β) simultaneously
up-regulated grass carp IL-1β (gcIL-1β) and TGF-β1 (gcTGF-β1) expression via NF-κB and …

In mammals, interleukin-10 (IL-10) is known as a potent regulatory cytokine with pleiotropic
effects on various leukocytes. Although teleost IL-10 has been identified in several fish …

Abstract Interleukin-6 (IL-6) is a multifunctional inflammatory cytokine which exists in multiple
tissues and cell lines. In the present study, the full-length cDNA and the genomic sequence …

In this study, the roles of reactive oxygen species (ROS) and NF-κB on inflammation
induction in lipopolysaccharide (LPS)-stimulated zebrafish embryos were evaluated using N …

B cell lymphoma/leukemia 10 (BCL10) is an important member of the caspase recruitment
domain-containing (CARD) protein family, which plays crucial roles in mediating the host …

Transforming growth factor-β-activating kinase 1 (TAK1) is triggered by foreign pathogenic
infection and involves in proinflammatory response through the activation of nuclear factor …

Toll-like receptor (TLR) signaling pathway plays a crucial role in innate immune responses.
In the present study, we first identified and characterized a key TLR pathway signal …

Lipopolysaccharide (LPS) is a classical pathogen-associated molecular pattern that can
trigger strong inflammatory response mainly by TLR4-mediated signaling pathway in …