Background Patients with depression who are treated in primary care practices may receive
antidepressants for prolonged periods. Data are limited on the effects of maintaining or …

Background Antidepressant use is often prolonged in patients with anxiety and/or
depressive disorder (s) compared with recommendations in treatment guidelines to …

Background: Studies of the adverse effects of antidepressants tend to focus on biological
symptoms. The prevalence of suicidality and withdrawal effects are currently a source of …

BackgroundAntidepressant drugs are usually prescribed at low doses, possibly to avoid
adverse reactions. No comprehensive review has addressed the issue of dose, clinical …

Antidepressant prescribing has increased year on year since the introduction of the selective
serotonin reuptake inhibitors (SSRIs) in the 1980s. More than 10% of adults in England are …

Rationale Premature discontinuation of antidepressant drugs is a frequent clinical problem.
Adverse effects are common, occur early on in treatment and are reported to be one of the …

Computerized pharmacy records from a large staffmodel health maintenance organization
were used to examine patterns of antidepressant use by primary care physicians and …

Importance Antidepressant use is increasing worldwide. Yet, contrasting evidence on the
safety of antidepressants is available from meta-analyses, and the credibility of these …

Side effects of antidepressants are usually underreported in clinical trials and large scale
naturalistic studies are restricted to six months of use. We examined the prevalence and …

Background: Despite the availability of effective antidepressants, recurrence and relapse
rates for depression are high (up to 80%), treatment failures are common (40% to 60%), and …