Insufficient activity of the bone-forming osteoblasts leads to low bone mass and predisposes
to fragility fractures. The functional capacity of human mesenchymal stem cells (hMSCs), the …

Osteoarthritis (OA) is a degenerative joint disease and a leading cause of global disability in
people over the age of 50. A genome-wide DNA methylation meta-analysis performed in our …

Osteoporosis is one of the most common age‐related progressive bone diseases in elderly
people. Approximately one in three women and one in five men are predisposed to …

Purpose: Osteoarthritis (OA) is a complex disease clinically characterized by chronic joint
pain, stiffness and progressive deformity. Affecting more than 40% of people over the age of …

Osteoarthritis (OA) is a common, painful and debilitating disease of articulating joints
resulting from the age-associated loss of cartilage. Well-powered genetic studies have …

Purpose: Heritability of hand osteoarthritis (OA) has been estimated to be as high as 65%.
Despite having a strong genetic component, genome-wide linkage and association studies …

RELATIONSHIPS BETWEEN DNA METHYLATION AND MUSCULOSKELETAL HEALTH
FROM AN EPIGENOME WIDE ASSOCIATION STUDY: THE HERTFORDSHIRE COHORT …

Purpose: Osteoarthritis (OA), the most prevalent degenerative joint disease, is characterized
by articular cartilage degradation and osteophyte formation. Signals for endochondral …

The aim of this study is to identify osteoarthritis (OA)-associated differentially methylated
genes in human articular chondrocytes from patients with OA. DNA methylation profiling of …

There is an evolving body of evidence that demonstrates the role of epigenetic mechanisms,
such as DNA-methylation in the pathogenesis of OA. This systematic review aims to …