Chronic low back pain (cLBP) that cannot be attributable to a specific pathoanatomical
change is associated with high personal and societal costs. Still, the underlying mechanism …

Epigenetic changes in articular chondrocytes are associated with osteoarthritis (OA) disease
progression. Numerous studies have identified differentially methylated cytosines in OA …

Purpose: Epigenetic mechanisms like DNA methylation may play a role in OA. For example,
expression of GDF5, a well-known OA gene, is modulated by demethylation of the …

Objective To identify osteoarthritis (OA) progression–modulating pathways in articular
cartilage and their respective regulatory epigenetic and genetic determinants in end‐stage …

Fig 5.(A) Receiver operating characteristic (ROC) for the target genes. ROC curve
measuring specificity (y axis) and sensitivity (x axis) of methylation of CG sites in ZNF267 …

Objective The aim of this work was to characterize the genome-wide DNA methylation profile
of cartilage from three regions of tibial plateau isolated from patients with primary knee …

Purpose: The vast majority of OA genetic risk-conferring alleles mediate their effect by
modulating the expression of a target gene. These are known as expression quantitative trait …

Background The study aimed to analyze aberrantly methylated genes, relevant pathways
and transcription factors (TFs) in osteosarcoma (OS) development. Methods Based on the …

Osteoporosis is a systemic disease characterized by low bone mass and microarchitectural
deterioration of bone tissue, with a consequent increase in bone fragility and propensity to …

DNA methylation is one of the most studied epigenetic mechanisms that play a pivotal role in
regulating gene expression. The epigenetic component is strongly involved in aging-bone …