Objectives: Epigenetic mechanisms, and in particular cytosine methylation in the promoter
regions, modulate the expression of many genes. However, their role in skeletal …

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …

Osteoarthritis is a complex degenerative joint disease. Here, we investigate matched
genotype and methylation profiles of primary chondrocytes from macroscopically intact (low …

Both genetic and environmental factors are involved in the pathogenesis of osteoporosis
and other skeletal disorders. Epidemiological studies have revealed an influence of a variety …

The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being
obesity, age, environmental variables, and genetic predisposition. The available evidence …

Osteoarthritis (OA) is a chronic musculoskeletal disease characterised by the destruction of
articular cartilage, synovial inflammation and bone remodelling. Disease aetiology is …

Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by
degradation and calcification of articular cartilage. Presently, no effective treatment other …

Bone mass can change intra-individually due to aging or environmental factors.
Understanding the regulation of bone metabolism by epigenetic factors, such as DNA …

GOMEZ, Rodolfo et al. DNA methylation analysis identifies key transcription factors involved
in mesenchymal stem cell osteogenic differentiation. Biol. Res.[online]. 2023, vol. 56, 9 …

The pathophysiology of osteoarthritis (OA) is multifactorial, with the primary risk factors being
obesity, age, environmental variables, and genetic predisposition. The available evidence …