Structure-activity relationships in a series of auranofin analogues showing remarkable antiproliferative properties
The antiproliferative properties of a series of structurally-related gold (I) and silver (I) linear
complexes inspired to the clinically established gold-based drug auranofin were …
complexes inspired to the clinically established gold-based drug auranofin were …
Replacement of the thiosugar of auranofin with iodide enhances the anticancer potency in a mouse model of ovarian cancer
In recent years, a few successful attempts were made to repurpose the clinically approved
antiarthritic gold drug, Auranofin (AF), as an anticancer agent. The present study shows that …
antiarthritic gold drug, Auranofin (AF), as an anticancer agent. The present study shows that …
[HTML][HTML] Chemical modification of Auranofin yields a new family of anticancer drug candidates: the gold (I) phosphite analogues
A panel of four novel gold (I) complexes, inspired by the clinically established gold drug
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …
[HTML][HTML] Selection and characterization of a human ovarian cancer cell line resistant to auranofin
The anti-arthritic drug auranofin exerts also potent antitumour activity in in vitro and in vivo
models, whose mechanisms are not yet well defined. From an auranofin-sensitive human …
models, whose mechanisms are not yet well defined. From an auranofin-sensitive human …
Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs
A Bindoli, MP Rigobello, G Scutari, C Gabbiani… - Coordination Chemistry …, 2009 - Elsevier
The thioredoxin system plays a key role in regulating the overall intracellular redox balance.
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …
Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold (III) compounds studied with combined mass spectrometry …
C Gabbiani, G Mastrobuoni, F Sorrentino, B Dani… - …, 2011 - pubs.rsc.org
The seleno-enzyme thioredoxin reductase (TrxR) is a putative target for cytotoxic gold
complexes. We investigated the mechanism of TrxR inhibition by a group of structurally …
complexes. We investigated the mechanism of TrxR inhibition by a group of structurally …
[HTML][HTML] Antiproliferative properties of a few auranofin-related gold (I) and silver (I) complexes in leukemia cells and their interferences with the ubiquitin proteasome …
A group of triethylphosphine gold (I) and silver (I) complexes, structurally related to
auranofin, were prepared and investigated as potential anticancer drug candidates. The …
auranofin, were prepared and investigated as potential anticancer drug candidates. The …
Reactivity of auranofin with selenols and thiols–implications for the anticancer activity of gold (I) compounds
The enzyme thioredoxin reductase (TrxR) is attracting much interest as a potential target for
cancer therapy. The presence of a selenium atom in the catalytic site makes it sensitive to …
cancer therapy. The presence of a selenium atom in the catalytic site makes it sensitive to …
Synthesis, chemical characterization, and biological evaluation of a novel auranofin derivative as an anticancer agent
A novel gold (I) complex inspired by the known medicinal inorganic compounds auranofin
and thimerosal, namely ethylthiosalicylate (triethylphosphine) gold (I)(AFETT hereafter), was …
and thimerosal, namely ethylthiosalicylate (triethylphosphine) gold (I)(AFETT hereafter), was …
Potential anticancer activity of auranofin
T Onodera, I Momose, M Kawada - Chemical and Pharmaceutical …, 2019 - jstage.jst.go.jp
Gold compounds have a long history of use in medicine. Auranofin was developed more
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …