The antiproliferative properties of a series of structurally-related gold (I) and silver (I) linear
complexes inspired to the clinically established gold-based drug auranofin were …

In recent years, a few successful attempts were made to repurpose the clinically approved
antiarthritic gold drug, Auranofin (AF), as an anticancer agent. The present study shows that …

A panel of four novel gold (I) complexes, inspired by the clinically established gold drug
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …

The anti-arthritic drug auranofin exerts also potent antitumour activity in in vitro and in vivo
models, whose mechanisms are not yet well defined. From an auranofin-sensitive human …

The thioredoxin system plays a key role in regulating the overall intracellular redox balance.
It basically comprises the small redox protein thioredoxin (Trx), nicotinamide adenine …

The seleno-enzyme thioredoxin reductase (TrxR) is a putative target for cytotoxic gold
complexes. We investigated the mechanism of TrxR inhibition by a group of structurally …

A group of triethylphosphine gold (I) and silver (I) complexes, structurally related to
auranofin, were prepared and investigated as potential anticancer drug candidates. The …

The enzyme thioredoxin reductase (TrxR) is attracting much interest as a potential target for
cancer therapy. The presence of a selenium atom in the catalytic site makes it sensitive to …

A novel gold (I) complex inspired by the known medicinal inorganic compounds auranofin
and thimerosal, namely ethylthiosalicylate (triethylphosphine) gold (I)(AFETT hereafter), was …

Gold compounds have a long history of use in medicine. Auranofin was developed more
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …