The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …

Complement factor C3 is the central component of the complement system and a key
inflammatory protein activated in Alzheimer's disease (AD). Previous studies demonstrated …

Complement pathway overactivation can lead to neuronal damage in various neurological
diseases. Although Alzheimer's disease (AD) is characterized by β-amyloid plaques and tau …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …

Abnormal accumulation of β-amyloid (Aβ) in Alzheimer's disease (AD) is associated with
prominent brain inflammation. Whereas earlier studies concluded that this inflammation is …

Alzheimer's disease (AD) is a neurodegenerative disease resulting in progressive cognitive
decline. Amyloid plaque deposits consisting specifically of β‐amyloid peptides that have …

Background Complement proteins and activation products have been found associated with
neuropathology in Alzheimer's disease (AD). Recently, a C5a receptor antagonist was …

CX3CR1 is a chemokine receptor expressed on microglia that binds Fractalkine (CX3CL1)
and regulates microglial recruitment to sites of neuroinflammation. Full deletion of CX3CR1 …

An estimated 5.7 million Americans suffer from Alzheimer's disease in the United States, with
no disease-modifying treatments to prevent or treat cognitive deficits associated with the …

The complement system is part of the innate immune response responsible for removing
pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via …