This study aimed at elucidating the physiological basis of bacterial antibiotic tolerance. By
use of a combined phenotypic and gene knockout approach, exogenous nutrient …

Bacteria encounter a myriad of potentially growth-compromising conditions in nature and in
hosts of pathogenic bacteria. These 'stresses' typically elicit protective and/or adaptive …

Antibiotics affect bacterial cell physiology at many levels. Rather than just compensating for
the direct cellular defects caused by the drug, bacteria respond to antibiotics by changing …

Resistance evolution during exposure to non-lethal levels of antibiotics is influenced by
various stress responses of bacteria which are known to affect growth rate. Here, we aim to …

The ability to monitor the environment for toxic chemical and physical disturbances is
essential for bacteria that live in dynamic environments. The fundamental sensing …

Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Environmental stresses often co-occur when bacteria encounter antibiotic treatment inside
the human body. The cellular response to environmental stressors can alter the global gene …

Bacteria suffer various stresses in their unpredictable environment. In response, clonal
populations may exhibit cell-to-cell variation, hypothetically to maximize their survival. The …

Microbes exhibit short and long term responses when exposed to challenging
environmental conditions. To what extent these responses are correlated, what their …

Adaptive stress resistance in microbes is mostly attributed to the expression of stress
response genes, including heat-shock proteins. Here, we report a response of E. coli to heat …