Active starvation responses mediate antibiotic tolerance in biofilms and nutrient-limited bacteria

D Nguyen, A Joshi-Datar, F Lepine, E Bauerle… - Science, 2011 - science.org
Bacteria become highly tolerant to antibiotics when nutrients are limited. The inactivity of
antibiotic targets caused by starvation-induced growth arrest is thought to be a key …

Nonoptimal microbial response to antibiotics underlies suppressive drug interactions

T Bollenbach, S Quan, R Chait, R Kishony - Cell, 2009 - cell.com
Suppressive drug interactions, in which one antibiotic can actually help bacterial cells to
grow faster in the presence of another, occur between protein and DNA synthesis inhibitors …

Hormetic dose responses induced by antibiotics in bacteria: A phantom menace to be thoroughly evaluated to address the environmental risk and tackle the antibiotic …

I Iavicoli, L Fontana, E Agathokleous… - Science of the Total …, 2021 - Elsevier
The environmental contamination of antibiotics caused by their over or inappropriate use is
a major issue for environmental and human health since it can adversely impact the …

[PDF][PDF] Bacterial stress response

EZ Ron - The prokaryotes, 2006 - ndl.ethernet.edu.et
Most bacteria live in a dynamic environment where temperature, availability of nutrients, and
presence of various chemicals vary. Quick adaptation to these environmental changes is …

The SOS response increases bacterial fitness, but not evolvability, under a sublethal dose of antibiotic

C Torres-Barceló, M Kojadinovic… - … of the Royal …, 2015 - royalsocietypublishing.org
Exposure to antibiotics induces the expression of mutagenic bacterial stress–response
pathways, but the evolutionary benefits of these responses remain unclear. One possibility is …

Short-and long-term transcriptomic responses of Escherichia coli to biocides: a systems analysis

B Merchel Piovesan Pereira, X Wang… - Applied and …, 2020 - Am Soc Microbiol
The mechanisms of the bacterial response to biocides are poorly understood, despite their
broad application. To identify the genetic basis and pathways implicated in the biocide …

Variation in stress responses within a bacterial species and the indirect costs of stress resistance

T Ferenci, B Spira - Annals of the New York Academy of …, 2007 - Wiley Online Library
Bacteria can exhibit high levels of resistance to one or more environmental stresses such as
temperature, osmolarity, radiation, pH, starvation, as well as resistance to noxious chemicals …

Evolutionary potential, cross‐stress behavior and the genetic basis of acquired stress resistance in Escherichia coli

M Dragosits, V Mozhayskiy… - Molecular systems …, 2013 - embopress.org
Bacterial populations have a remarkable capacity to cope with extreme environmental
fluctuations in their natural environments. In certain cases, adaptation to one stressful …

Nonessential tRNA and rRNA modifications impact the bacterial response to sub-MIC antibiotic stress

A Babosan, L Fruchard, E Krin, A Carvalho, D Mazel… - …, 2022 - academic.oup.com
Antimicrobial resistance develops as a major problem in infectious diseases treatment.
While antibiotic resistance mechanisms are usually studied using lethal antibiotic doses …

Gene expression variability underlies adaptive resistance in phenotypically heterogeneous bacterial populations

KE Erickson, PB Otoupal, A Chatterjee - ACS infectious diseases, 2015 - ACS Publications
The root cause of the antibiotic resistance crisis is the ability of bacteria to evolve resistance
to a multitude of antibiotics and other environmental toxins. The regulation of adaptation is …