Cell-to-cell heterogeneity in gene expression and growth can have critical functional
consequences, such as determining whether individual bacteria survive or die following …

This report describes the identification and analysis of a 2-component regulator of
Pseudomonas aeruginosa that is a potential aminoglycoside antibiotic combination therapy …

The defense mechanisms of bacterial cells against antibiotics, which induce specific
complexes of adaptive reactions at the levels of replication, transcription, translation, and …

Bacterial pathogens are exposed to a variety of stressful conditions while spreading to and
colonizing new hosts to cause infection. Gastrointestinal pathogens such as Campylobacter …

Antibiotic resistance is often associated with metabolic costs. To investigate the metabolic
consequences of antibiotic resistance, the genomic and transcriptomic profiles of an …

Stress response helps microorganisms survive extreme environmental conditions and host
immunity, making them more virulent or drug resistant. Although both reductionist …

The delicate and dynamic balance of the physiological steady state and its maintenance is
well characterized by studies of bacterial stress response. Through the use of genetic …

In nature, bacteria frequently experience many adverse conditions, including heat, oxidation,
acidity, and hyperosmolarity, which all tend to slow down if not outright stop cell growth …

Most bacteria live in ever-changing environments where periods of stress are common. One
fundamental question is whether individual bacterial cells have an increased tolerance to …

Antibiotic treatment kills a large portion of a population, while a small, tolerant subpopulation
survives. Tolerant bacteria disrupt antibiotic efficacy and increase the likelihood that a …