Deeper understanding of antibiotic-induced physiological responses is critical to identifying
means for enhancing our current antibiotic arsenal. Bactericidal antibiotics with diverse …

Stress responses allow cells to adapt to changes in external conditions by activating specific
pathways. Here we investigate the dynamics of single cells that were subjected to acute …

The use of antibiotics leads to strong stresses to bacteria, leading to profound impact on
cellular physiology. Elucidating how bacteria respond to antibiotic stresses not only helps us …

Current approaches explore bacterial genes that change transcriptionally upon stress
exposure as diagnostics to predict antibiotic sensitivity. However, transcriptional changes …

Environmental stress is detrimental to cell viability and requires an adequate reprogramming
of cellular activities to maximize cell survival. We present a global analysis of the response …

Background A decline in the discovery of new antibacterial drugs, coupled with a persistent
rise in the occurrence of drug-resistant bacteria, has highlighted antibiotics as a diminishing …

Environmental stresses are usually active during the process of microbial fermentation and
have significant influence on microbial physiology. Microorganisms have developed a series …

Evolutionary innovations are dependent on mutations. Mutation rates are increased by
adverse conditions in the laboratory, but there is no evidence that stressful environments …

The stress-induced mutagenesis hypothesis postulates that in response to stress, bacteria
increase their genome-wide mutation rate, in turn increasing the chances that a descendant …

The acid stress response is an important factor influencing the transmission of intestinal
microbes such as the enterobacterium Escherichia coli. E. coli activates three inducible acid …