Non-genetic factors can cause significant fluctuations in gene expression levels. Regardless
of growing in a stable environment, this fluctuation leads to cell-to-cell variability in an …

Environmental fluctuations lead to a rapid adjustment of the physiology of Escherichia coli,
necessitating changes on every level of the underlying cellular and molecular network. Thus …

Antibiotic resistance is one of the few examples of evolution that can be addressed
experimentally. The present review analyses this resistance, focusing on the networks that …

The transition of Escherichia coli from the exponential into the stationary phase of growth
induces the stringent response, which is mediated by the rapid accumulation of the …

The increase in antibiotic non-responsive bacteria is the leading concern in current research
oriented to eliminate pathogens. Nowadays, the excess use of antibiotics without specifically …

Extracellular pH has been assumed to play little if any role in how bacteria respond to
antibiotics and antibiotic resistance development. Here, we show that the intracellular pH of …

Bacterial processes necessary for adaption to stressful host environments are potential
targets for new antimicrobials. Here, we report large-scale transcriptomic analyses of 32 …

The ability of Escherichia coli to tolerate acid stress is important for its survival and
colonization in the human digestive tract. Here, we performed adaptive laboratory evolution …

Background Economically viable biobased production of bulk chemicals and biofuels
typically requires high product titers. During microbial bioconversion this often leads to …