Mutations are an important origin of antibiotic resistance in bacteria. While there is
increasing evidence showing promoted resistance mutations by environmental stresses, no …

Antibiotics have revolutionized the treatment of infectious disease but have also rapidly
selected for the emergence of resistant pathogens. Traditional methods of antibiotic …

The metabolic state of a bacterial cell influences its susceptibility to antibiotics. In this issue,
Peng et al.(2015) show that resistant bacteria can be sensitized to antibiotic treatment …

Increased mutation rates under stress allow bacterial populations to adapt rapidly to
stressors, including antibiotics. Here we evaluate existing models for the evolution of stress …

Bacteria have evolved diverse mechanisms to survive environments with antibiotics.
Temperature is both a key factor that affects the survival of bacteria in the presence of …

Antibiotic resistance is one of the most challenging issues in public health. Antibiotics have
been increasingly used not only for humans and animals but also for crop protection as …

Antibiotic tolerance, or the ability of bacteria to survive antibiotic treatment in the absence of
genetic resistance, has been linked to chronic and recurrent infections. Tolerant cells are …

There is considerable understanding about how laboratory populations respond to
predictable (constant or deteriorating environment) selection for single environmental …

The ability to respond to acidic environments is crucial for neutralophilic bacteria.
Escherichia coli has a well-characterized regulatory network that triggers a multitude of …

Background Beneficial mutations play an essential role in bacterial adaptation, yet little is
known about their fitness effects across genetic backgrounds and environments. One …