Mapping Critical Interactive Sites within the Periplasmic Domain of the Vibrio cholerae Type II Secretion Protein EpsM

TL Johnson, ME Scott, M Sandkvist - Journal of bacteriology, 2007 - Am Soc Microbiol
The type II secretion (T2S) system is present in many gram-negative species, both
pathogenic and nonpathogenic, where it supports the delivery of a variety of toxins …

Two Regions of EpsL Involved in Species-Specific Protein-Protein Interactions with EpsE and EpsM of the General Secretion Pathway inVibrio cholerae

M Sandkvist, JM Keith, M Bagdasarian… - Journal of …, 2000 - Am Soc Microbiol
Extracellular secretion of proteins via the type II or general secretion pathway in gram-
negative bacteria requires the assistance of at least 12 gene products that are thought to …

Direct Interaction of the EpsL and EpsM Proteins of the General Secretion Apparatus in Vibrio cholerae

M Sandkvist, LP Hough, MM Bagdasarian… - Journal of …, 1999 - Am Soc Microbiol
The general secretion pathway of gram-negative bacteria is responsible for extracellular
secretion of a number of different proteins, including proteases and toxins. This pathway …

The X-ray structure of the type II secretion system complex formed by the N-terminal domain of EpsE and the cytoplasmic domain of EpsL of Vibrio cholerae

J Abendroth, P Murphy, M Sandkvist… - Journal of molecular …, 2005 - Elsevier
Gram-negative bacteria use type II secretion systems for the transport of virulence factors
and hydrolytic enzymes through the outer membrane. These sophisticated multi-protein …

Docking and Assembly of the Type II Secretion Complex of Vibrio cholerae

SR Lybarger, TL Johnson, MD Gray… - Journal of …, 2009 - Am Soc Microbiol
Secretion of cholera toxin and other virulence factors from Vibrio cholerae is mediated by the
type II secretion (T2S) apparatus, a multiprotein complex composed of both inner and outer …

Compromised Outer Membrane Integrity in Vibrio cholerae Type II Secretion Mutants

AE Sikora, SR Lybarger, M Sandkvist - Journal of bacteriology, 2007 - Am Soc Microbiol
The type II secretion (T2S) system of Vibrio cholerae is a multiprotein complex that spans the
cell envelope and secretes proteins important for pathogenesis as well as survival in …

Structural and functional studies of EpsC, a crucial component of the type 2 secretion system from Vibrio cholerae

KV Korotkov, B Krumm, M Bagdasarian… - Journal of molecular …, 2006 - Elsevier
The type 2 secretion system (T2SS) occurring in Gram-negative bacteria is composed of 12–
15 different proteins which form large assemblies spanning two membranes and secreting …

Characterization of the multimeric Eps complex required for cholera toxin secretion

M Sandkvist, M Bagdasarian, SP Howard - International journal of medical …, 2000 - Elsevier
Vibrio cholerae causes diarrheal disease through colonization of the small intestine. A
critical aspect of V. cholerae pathogenesis is its ability to actively secrete cholera toxin to the …

The three-dimensional structure of the cytoplasmic domains of EpsF from the type 2 secretion system of Vibrio cholerae

J Abendroth, DD Mitchell, KV Korotkov… - Journal of structural …, 2009 - Elsevier
The type 2 secretion system (T2SS), a multi-protein machinery that spans both the inner and
the outer membranes of Gram-negative bacteria, is used for the secretion of several critically …

The dimer formed by the periplasmic domain of EpsL from the Type 2 Secretion System of Vibrio parahaemolyticus

J Abendroth, AC Kreger, WGJ Hol - Journal of structural biology, 2009 - Elsevier
The Type 2 Secretion System (T2SS), occurring in many Gram-negative bacteria, is
responsible for the transport of a diversity of proteins from the periplasm across the outer …