Neuropathic pain is currently being treated by a range of therapeutic interventions that
above all act to lower neuronal activity in the somatosensory system (eg using local …

Advances in the characterization of pain signaling in recent years indicate that distinct
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …

Neuropathic pain is a debilitating form of treatment resistant chronic pain and responds
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …

There are two basic categories of pain: physiological pain, which serves an important
protective function, and pathological pain, which can have a major negative impact on …

Peripheral neuropathic pain, that clinical pain syndrome associated with lesions to the
peripheral nervous system, is characterized by positive and negative symptoms. Positive …

Neuropathic pain develops from a lesion or disease affecting the somatosensory system.
Translational investigations of neuropathic pain by using different animal models reveal that …

Neuropathic pain exerts a global burden caused by the lesions in the somatosensory nerve
system, including the central and peripheral nervous systems. The mechanisms of nerve …

Neuropathic pain is induced by injury or disease of the nervous system. Studies aimed at
understanding the molecular pathophysiology of neuropathic pain have so far focused on a …

Although pain is always intense and unpleasant, the capacity to experience this sensation
is, under normal circumstances, fundamental to the preservation of bodily integrity …

Increasing knowledge of the molecular consequences of nerve injury and the availability of
genome databases has greatly increased the range of potential targets for the …