Cellular and molecular insights into neuropathy-induced pain hypersensitivity for mechanism-based treatment approaches
JV Berger, L Knaepen, SPM Janssen, RJP Jaken… - Brain research …, 2011 - Elsevier
Neuropathic pain is currently being treated by a range of therapeutic interventions that
above all act to lower neuronal activity in the somatosensory system (eg using local …
above all act to lower neuronal activity in the somatosensory system (eg using local …
Neuropathic pain: models and mechanisms
JM Boyce-Rustay, MF Jarvis - Current pharmaceutical design, 2009 - ingentaconnect.com
Advances in the characterization of pain signaling in recent years indicate that distinct
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …
neurophysiological and neurochemical mechanisms contribute to pain arising from injury to …
Therapeutic targets for the management of peripheral nerve injury-induced neuropathic pain
A Singh Jaggi, N Singh - … Formerly Current Drug Targets-CNS & …, 2011 - ingentaconnect.com
Neuropathic pain is a debilitating form of treatment resistant chronic pain and responds
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …
Pain hypersensitivity mechanisms at a glance
V Gangadharan, R Kuner - Disease models & mechanisms, 2013 - journals.biologists.com
There are two basic categories of pain: physiological pain, which serves an important
protective function, and pathological pain, which can have a major negative impact on …
protective function, and pathological pain, which can have a major negative impact on …
Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy
CJ Woolf - Life sciences, 2004 - Elsevier
Peripheral neuropathic pain, that clinical pain syndrome associated with lesions to the
peripheral nervous system, is characterized by positive and negative symptoms. Positive …
peripheral nervous system, is characterized by positive and negative symptoms. Positive …
Translational investigation and treatment of neuropathic pain
Neuropathic pain develops from a lesion or disease affecting the somatosensory system.
Translational investigations of neuropathic pain by using different animal models reveal that …
Translational investigations of neuropathic pain by using different animal models reveal that …
Peripheral neuropathic pain: from experimental models to potential therapeutic targets in dorsal root ganglion neurons
TY Yeh, IW Luo, YL Hsieh, TJ Tseng, H Chiang… - Cells, 2020 - mdpi.com
Neuropathic pain exerts a global burden caused by the lesions in the somatosensory nerve
system, including the central and peripheral nervous systems. The mechanisms of nerve …
system, including the central and peripheral nervous systems. The mechanisms of nerve …
Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases
H Wang, H Sun, K Della Penna, RJ Benz, J Xu… - Neuroscience, 2002 - Elsevier
Neuropathic pain is induced by injury or disease of the nervous system. Studies aimed at
understanding the molecular pathophysiology of neuropathic pain have so far focused on a …
understanding the molecular pathophysiology of neuropathic pain have so far focused on a …
Pain mechanisms and management: a central perspective
RJ Mannion, CJ Woolf - The Clinical journal of pain, 2000 - journals.lww.com
Although pain is always intense and unpleasant, the capacity to experience this sensation
is, under normal circumstances, fundamental to the preservation of bodily integrity …
is, under normal circumstances, fundamental to the preservation of bodily integrity …
New and emerging pharmacological targets for neuropathic pain
DC Manning - Current pain and headache reports, 2004 - Springer
Increasing knowledge of the molecular consequences of nerve injury and the availability of
genome databases has greatly increased the range of potential targets for the …
genome databases has greatly increased the range of potential targets for the …