Isoorientin induces apoptosis, decreases invasiveness, and downregulates VEGF secretion by activating AMPK signaling in pancreatic cancer cells

T Ye, J Su, C Huang, D Yu, S Dai, X Huang… - OncoTargets and …, 2016 - Taylor & Francis
Isoorientin (or homoorientin) is a flavone, which is a chemical flavonoid-like compound, and
a 6-C-glucoside of luteolin. Isoorientin has been demonstrated to have anti-cancer activities …

A mechanism of isoorientin-induced apoptosis and migration inhibition in gastric cancer AGS cells

T Zhang, YH Xiu, H Xue, YN Li, JL Cao, WS Hou, J Liu… - Pharmaceuticals, 2022 - mdpi.com
Isoorientin (ISO) is a flavonoid compound containing a luteolin structure, which can induce
autophagy in some tumor cells. This study investigated the impact of ISO in gastric cancer …

Isoorientin induces the apoptosis and cell cycle arrest of A549 human lung cancer cells via the ROS-regulated MAPK, STAT3 and NF-κB signaling pathways

WT Xu, GN Shen, TZ Li, Y Zhang… - International …, 2020 - spandidos-publications.com
Isoorientin (ISO) is a naturally occurring C-glycosyl flavone that has various pharmacological
properties, such as anti-bacterial and anti-inflammatory effects. However, its underlying …

Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells

L Yuan, J Wang, H Xiao, C Xiao, Y Wang… - Toxicology and applied …, 2012 - Elsevier
Isoorientin (ISO) is a flavonoid compound that can be extracted from several plant species,
such as Phyllostachys pubescens, Patrinia, and Drosophyllum lusitanicum; however, its …

[HTML][HTML] Investigation of the anticancer mechanism of isoorientin isolated from Eremurus spectabilis leaves via cell cycle pathways in HT-29 human colorectal …

G Gundogdu, Y Dodurga, L Elmas… - The Eurasian Journal …, 2018 - ncbi.nlm.nih.gov
Objective Isoorientin (ISO) is a flavonoid compound extracted from plant species. The goal of
this study was to determine the potential antiproliferative effects of ISO in HT-29 human …

[HTML][HTML] Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair

D Huang, Z Li, J Wu, N Zhang, D Zhou, X Ni… - Biomedicine & …, 2018 - Elsevier
Hepatoblastoma (HB) is the most common malignant liver tumor in children. DNA and DNA-
associated processes are one of the most important targets of chemotherapeutic agents …

Isoorientin induces apoptosis and autophagy simultaneously by reactive oxygen species (ROS)-related p53, PI3K/Akt, JNK, and p38 signaling pathways in HepG2 …

L Yuan, S Wei, J Wang, X Liu - Journal of Agricultural and Food …, 2014 - ACS Publications
Cell death is closely related to autophagy under some circumstances; however, the effect of
isoorientin (ISO) on autophagy and the interplay between apoptosis and autophagy in …

Isoorientin attenuates doxorubicin-induced cardiac injury via the activation of MAPK, Akt, and Caspase-dependent signaling pathways

S Li, H Liu, Z Lin, Z Li, Y Chen, B Chen, L Huang, X Lin… - Phytomedicine, 2022 - Elsevier
Background Chemotherapy drugs especially anthracyclines are widely used in the treatment
of hematological malignancies and solid tumors. However, their clinical application is limited …

Orientin regulates the proliferation and migration of hepatocellular carcinoma cells

JY Tao, J Li, L Wan, BZ Dong, YJ Yu, YM Liu… - Naunyn-Schmiedeberg's …, 2023 - Springer
Orientin is a flavone isolated from medicinal plants used in traditional Chinese medicine
(TCM) that suppresses the growth of cancer cells in vitro. The effects of orientin in hepatoma …

Orientin induces G0/G1 cell cycle arrest and mitochondria mediated intrinsic apoptosis in human colorectal carcinoma HT29 cells

K Thangaraj, B Balasubramanian, S Park, K Natesan… - Biomolecules, 2019 - mdpi.com
Colorectal carcinoma is one of the utmost diagnosed cancer with a steep increase in
mortality rate. The incidence has been increasing in developing countries like India due to a …