Towards improved therapeutic CORMs: understanding the reactivity of CORM-3 with proteins

T Santos-Silva, A Mukhopadhyay… - Current medicinal …, 2011 - ingentaconnect.com
The biological role of carbon monoxide (CO) has completely changed in the last decade.
Beyond its widely feared toxicity, CO has revealed a very important biological activity as a …

A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ3N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli

N Rana, HE Jesse, M Tinajero-Trejo… - …, 2017 - microbiologyresearch.org
Carbon monoxide-releasing molecules (CORMs) are a promising class of new
antimicrobials, with multiple modes of action that are distinct from those of standard …

Carbon monoxide is a poison… to microbes! CO as a bactericidal molecule

BY Chin, LE Otterbein - Current opinion in pharmacology, 2009 - Elsevier
Inflammation and immunity result in a wide range of disease processes, including chronic
obstructive pulmonary disease, ischemia–reperfusion injury, atherosclerosis, vascular …

[HTML][HTML] Gasotransmitters, poisons, and antimicrobials: it's a gas, gas, gas!

M Tinajero-Trejo, HE Jesse, RK Poole - F1000prime reports, 2013 - ncbi.nlm.nih.gov
We review recent examples of the burgeoning literature on three gases that have major
impacts in biology and microbiology. NO, CO and H 2 S are now co-classified as …

Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes

R Alberto, R Motterlini - Dalton Transactions, 2007 - pubs.rsc.org
The advent of CO as a small molecule that, in addition to NO, elicits essential biological
functions has initiated the search for compounds and complexes capable of releasing CO in …

Bioactive properties of iron-containing carbon monoxide-releasing molecules

P Sawle, J Hammad, IJS Fairlamb, B Moulton… - … of Pharmacology and …, 2006 - ASPET
Carbon monoxide-releasing molecules (CO-RMs) are compounds capable of delivering
controlled amounts of CO within a cellular environment. Ruthenium-based carbonyls …

Strategies toward organic carbon monoxide prodrugs

X Ji, B Wang - Accounts of Chemical Research, 2018 - ACS Publications
Conspectus Carbon monoxide is widely acknowledged as an important gasotransmitter in
the mammalian system with importance on par with that of nitric oxide. It has also been firmly …

CO–metal interaction: vital signaling from a lethal gas

J Boczkowski, JJ Poderoso, R Motterlini - Trends in biochemical sciences, 2006 - cell.com
The past few years have witnessed intense research into the biological significance of
carbon monoxide (CO) as an essential signaling mediator in cells and tissues. To transduce …

Generation of carbon monoxide releasing molecules (CO-RMs) as drug candidates for the treatment of acute liver injury: targeting of CO-RMs to the liver

AR Marques, L Kromer, DJ Gallo, N Penacho… - …, 2012 - ACS Publications
The discovery of the biological effects of carbon monoxide (CO) in recent years strongly
suggests that CO could find applications as a therapeutic agent. CO is a highly toxic gas …

Feedback response to selective depletion of endogenous carbon monoxide in the blood

H Kitagishi, S Minegishi, A Yumura… - Journal of the …, 2016 - ACS Publications
The physiological roles of endogenous carbon monoxide (CO) have not been fully
understood because of the difficulty in preparing a loss-of-function phenotype of this …